Research list

Analysis of Protein and Gene Expression in Blood Cells from Patients with Hematologic Disorders

Expression profiling

NGS
(RNA-seq)

cGVHD: 4 cases
hematologic disorders (controls): 3 cases
(Japanese)

A study for the establishment of disease-specific iPS cells.

Sequencing
Expression profiling
Histone modification

NGS
(Exome, RNA-seq, ChIP-seq)

120 + 2 Healthy volunteers
(Japanese)

Development of culturing methods amplifying micro-specimens derived from human pancreas and biliary tract tissues

Sequencing, Expression profiling, Chromatin structure profiling, Histone modification profiling

NGS
(Exome, RNA-seq, ATAC-seq, ChIP-seq, Hi-C)

Pancreatic ductal adenocarcinoma: 17 cases
Intraductal papillary mucinous neoplasm (IPMN): 6+3 cases
Pancreatic cancer: 11 cases
IPMN-derived pancreatic cancers: 2 cases
Non-tumor pancreatic tissue: 1 case
(Japanese)

Research on constructing a genome analysis database for malignant tumors

Sequencing, Expression profiling

NGS
(Exome, RNA-seq, WGS)

rectal cancer: 2 cases
gastric adenocarcinoma: 4 cases
colorectal cancer: 32 cases
(Japanese)

Single cell analysis of tumor-infiltrating T cells

Sequencing, Expression profiling

NGS
(Exome, RNA-seq, scRNA-seq, scTCR-seq)

esophageal cancer: 28 cases
gastric cancer: 12 cases
gastroesophageal junction cancer: 2 cases
(Japanese)

Registered research projects for new genetic test analysis data in the restricted-access database

Sequencing

NGS (Targeted DNA-seq, Targeted RNA-seq)

xeroderma pigmentosum: 1 case
(Japanese)

Genetic Mutation Spectrum Analysis in Bone and Soft Tissue Sarcomas

Sequencing,
Expression profiling

NGS (Exome, RNA-seq)

myxoid liposarcoma: 72cases
(Japanese)
ヒト粘液型脂肪肉腫細胞株: 3 samples
(Cell-line)

Genomic Analysis of Digestive System Malignancies and Precancerous Lesions

Sequencing

NGS (Exome)

IPNB: 10 cases
(Japanese)

The Molecular Biological Analysis about Occurrence and Malignant Transformation in gynecological carcinogenesis

Genome-wide CNV analysis, sequencing, expression profiling, methylation profiling

SNP-chip, NGS (Exome, RNA-seq, Target bisulfite-seq), Methylation array, Expression array, Xenium In Situ Gene Expression

57 + 111 + 31 + 189 Ovarian carcinomas
86 Endometrial cancers
8 Uterine carcinosarcomas
(Japanese)

Study of anti-malignant cancer drug target using human CRC patient samples

Sequencing,
Expression profiling

NGS
(Exome, RNA-seq)

colorectal cancer: 1 case
(Japanese)

A Basic Investigation of Factors Affecting the Analytical Performance of Whole-Genome Sequencing and Related Analyses Using Tissue Specimens from Patients with Solid Tumors

Sequencing, Expression profiling

NGS
(WGS, RNA-seq)

Endometrial cancer: 1 case
(Japanese)
Breast cancer cell line-derived xenograft: 1 model
(Cell line)

Explore genetic abnormalities, molecular targets, predictive of drug sensitivity, histomorphology, and biomarkers in lung cancer / Analysis of genetic abnormalities and their biological significance in lung cancer

Sequencing; Expression profiling;

NGS (WGS, Visium Spatial Gene Expression, snRNA-seq, STOmics); Xenium In Situ Gene Expression; Histological image; Spatial Proteomics

pulmonary neuroendocrine carcinoma: 10+ 10 + 13 cases
(Japanese)

Research on new diagnosis and clinical picture of lymphoproliferative diseases by combining genetic analysis and immunological traits

Sequencing

NGS
(Target Capture, Exome)

Waldenström macroglobulinemia: 10 cases
non IgM-type lymphoplasmacytic lymphoma: 10 cases
T cell lymphoproliferative disease: 1 case
(Japanese)

Exploratory Biomarker Study Associated with the Investigator-Initiated Clinical Trial of Alectinib for Rare Cancers Harboring ALK Alterations

Sequencing

NGS
(Target capture)

Rare cancers harboring ALK alterations: 24 cases
(Japanese)

Identification of Molecular Markers and Elucidation of Molecular Mechanisms in Aging Using Centenarian Samples

Expression profiling

NGS
(scRNA-seq, scTCR-seq, scCITE-seq, bulk RNA-seq)

28 healthy individuals
(Japanese)

The mutiomics analysis on liver tumor with rare liver diseases, including Fontan associated liver diseases

Sequencing; Expression profiling

NGS
(WGS, RNA-seq)

liver cancer caused by rare liver diseases: 13 cases
(Japanese)

Elucidation of the Molecular Mechanisms of Advanced Thyroid Cancer through Single-Cell Gene Expression Analysis

Expression profiling

NGS
(scRNA-seq)

undifferentiated thyroid carcinoma: 3 cases
papillary thyroid carcinoma: 3 cases
(Japanese)

Immune profiling study of COVID-19 vaccine recipients

Expression profiling

NGS
(scRNA-seq, scTCR-seq)

14 healthy donors who received COVID-19 vaccines
(Japanese)

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

Expression profiling

NGS
(RNA-seq)

undifferentiated iPS cells and differentiated cardiomyocytes: 12 samples
(Cell-line)

Research of genetic abnormalities related to the development and prognosis of adenocarcinoma and squamous cell carcinoma of the cervix and vaginal and vulvar cancer

Sequencing, Expression profiling, Methylation profiling

NGS (Exome, RNA-seq, scRNA-seq, Target bisulfite-seq); Xenium In Situ Gene Expression

cervical cancer: 19 + 4 + 96 cases
(Japanese)
NIKS18 cell line: 5 samples
(Cell-line)