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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0489-v1Release info

Latest

Research title

Genetic Mutation Spectrum Analysis in Bone and Soft Tissue Sarcomas

Research overview

Aims
Bone and soft tissue sarcomas are rare, incurable cancers. Approximately 30% of patients have fusion gene formation due to chromosomal translocations, but other genetic mutations and genomic abnormalities are not well understood. The aim of this study is to identify genetic abnormalities that may be important in the progression and malignant transformation of fusion gene-positive bone and soft tissue sarcomas and to contribute to the analysis of sarcoma pathogenesis and the development of novel molecularly targeted therapies.
Methods
whole exon sequencing and RNA sequencing
Participants/materials
- Surgically resected tumors from patients diagnosed with myxoid liposarcoma at the Cancer Institute Hospital of Japanese Foundation For Cancer Research.
WES: 43 patients (43 tumor tissue samples)
RNA-seq: 72 patients (72 tumor tissue samples)
For 43 cases, both WES and RNA-seq analyses were performed.
- human myxoid liposarcoma cell lines (402-91、1955-91、2645-94)
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000909NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)

Data provider

Principal investigator
Koji Ueda
Affiliation
Project for Realization of Personalized Cancer Medicine, Cancer Precision Medicine Center, Japanese Foundation For Cancer Research

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (A)
Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma
  • 16H02676
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)
Screening of therapeutic targets and biomarkers for bone and soft tissue tumors by multiomics analysis
  • JP21cm0106578

Related publications

TitleDOIDataset ID
Proteogenomic characterization of myxoid liposarcoma reveals molecular features associated with poor prognosis

Controlled access users

No use of the controlled access data has been recorded.