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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0553-v1Release info

Latest

Research title

Study of anti-malignant cancer drug target using human CRC patient samples

Research overview

Aims
Gastrointestinal cancer is the leading cause of cancer-related death, and the 5-year survival rate drops significantly for patients with metastasis. To study the mechanisms of malignant progression, tumor samples are collected from patients at different stages and organoids are established. Using these organoids, anti-cancer drug targets are identified by gene expression analysis, or PDX model analysis, drug screening analysis.
Methods
Whole exome sequencing, RNA sequencing
Participants/materials
A colorectal cancer patient who underwent surgical resection of liver metastasis.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001019NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)

Data provider

Principal investigator
Masanobu Oshima
Affiliation
Nano Life Science Institute, Kanazawa University

Research projects

NameURL
N/A
N/A

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (A)
Mechanisms of Gastric cancer Progression and Metastasis Driven by Exogenous Ligand-dependent Wnt Signaling
  • 22H00454
KAKENHI Grant-in-Aid for Scientific Research (C)
Intratumoral Microenvironment Associated with Heterogenous accumulation of Mutant p53
  • 23K06631

Related publications

No related publications.

Controlled access users

No use of the controlled access data has been recorded.