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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0574-v1Release info

Latest

Research title

Construction of a genome analysis database for malignant tumors

Research overview

Aims
To build a comprehensive genome analysis database for malignant tumors and to analyze the pathology of malignant tumors from multiple angles, thereby clarifying the relationship between genome information and clinical course, developing diagnostic techniques using artificial intelligence, and developing new treatments.
Methods
Total RNA extracted from fresh frozen tissues using the RNeasy Plus Universal Mini Kit was used for RNA sequencing. Genomic DNA extracted from the FFPE and from fresh-frozen tissues using the Maxwell RSC DNA FFPE Kit and Maxwell RSC Tissue DNA Kit (Promega, Madison, WI, USA), respectively was used for whole exome sequencing.
Participants/materials
Two patients with rectal cancer (one with POLE mutation-positive, the other one with POLE mutation-negative), four patients with histologically confirmed gastric adenocarcinoma who were carriers of germline pathogenic variants (GPVs) in BRCA1/2 detected by germline BRCA1/2 testing.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001063NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)2026-07-27
JGAD001064NGS (Exome)
  • WES
Controlled-access (Type I)2026-07-27

Data provider

Principal investigator
Yoshifumi Shimada
Affiliation
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
Principal investigator
Hiroshi Ichikawa
Affiliation
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Elucidation of the molecular mechanisms underlying the response to chemoradiotherapy in rectal cancer through analysis of dynamic immune responses
  • 25K11923
KAKENHI Grant-in-Aid for Scientific Research (C)
Molecular Characteristics and Clinical Outcome of Gastric Cancer with Germline Mutation in Homologous Recombination Repair Genes
  • 25K12021

Related publications

No related publications.

Controlled access users

No use of the controlled access data has been recorded.