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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0606-v1Release info

Latest

Research title

A Basic Investigation of Factors Affecting the Analytical Performance of Whole-Genome Sequencing and Related Analyses Using Tissue Specimens from Patients with Solid Tumors

Research overview

Aims
To support the development of standard operating procedures for specimen handling at medical institutions responsible for returning results to patients under the nationwide framework for whole-genome sequencing and related analyses that is expected to be established in Japan, tissue specimens prepared using multiple processing methods will be comparatively evaluated. Genetic alterations, gene expression profiles, and other data obtained through whole-genome sequencing and related analyses will be compared to generate empirical evidence on factors, such as specimen quality, that may affect analytical performance.
Methods
Whole Genome Sequencing, RNA Sequencing
Participants/materials
WGS:
- Endometrial cancer, 1 patient: 1 fresh-frozen tumor tissue, 1 cytology specimen, and 1 peripheral blood specimen as a matched normal control.
- Breast cancer cell line-derived xenograft, 1 model: 1 fresh-frozen tumor tissue, 1 cytology specimen, and 1 cell pellet.
RNA-seq:
- Endometrial cancer, 1 patient: 1 fresh-frozen tumor tissue and 1 cytology specimen.
- Breast cancer cell line-derived xenograft, 1 model: 1 fresh-frozen tumor tissue and 1 cytology specimen.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001101NGS（WGS）
  • WGS
Controlled-access (Type I)
JGAD001102NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)

Data provider

Principal investigator
Yutaka Hatanaka
Affiliation
Center for Development of Advanced Diagnostics, Hokkaido University Hospital

Research projects

No research projects.

Grants

NameTitleProject number
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)
Research on genome and clinical information infrastructure for returning whole genome information to patients
  • JP21ck0106696

Related publications

No related publications.

Controlled access users

No use of the controlled access data has been recorded.