Research ID
hum0257-v3Release info
Latest
Research title
Development of culturing methods amplifying micro-specimens derived from human pancreas and biliary tract tissues
Research overview
- Aims
- In this study, we establish organoids using minimal tumor tissue obtained via biopsy or cytology. These organoids are then amplified and cultured to enable various analyses using tumor tissue from individual patients. By comparing the results of these analyses with clinical and pathological factors, we aim to gain insights that will lead to the identification of effective treatments and novel drugs for individual tumors.
- Methods
- Whole Exome sequencing, RNA sequencing, ATAC sequencing, ChIP sequencing, and Hi-C analysis using organoids established from pancreatic cancer and Intraductal Papillary Mucinous Neoplasm (IPMN).
Long read RNA-seq analysis using organoids established from pancreatic cancer, IPMN, IPMN-derived pancreatic cancers and Non-tumor pancreatic tissue. - Participants/materials
- Pancreatic ductal adenocarcinoma, IPMN, Pancreatic cancer, IPMN-derived pancreatic cancers , Non-tumor pancreatic tissue
- URL
- N/A
Datasets
| Cart | Dataset ID | Type of data | Platforms | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000366 | NGS (Exome, RNA-seq) |
| Controlled-access (Type I) | 2021-12-27 | |
| E-GEAD-414 | NGS (RNA-seq) |
| Unrestricted-access | 2021-12-27 | |
| JGAD000367 | NGS (ATAC-seq, ChIP-seq) |
| Controlled-access (Type I) | 2021-12-24 | |
| E-GEAD-416 | NGS (ATAC-seq) |
| Unrestricted-access | 2021-12-27 | |
| E-GEAD-417 | NGS (ChIP-seq) |
| Unrestricted-access | 2021-12-27 | |
| JGAD000365 | NGS (Hi-C) |
| Controlled-access (Type I) | 2021-12-24 | |
| E-GEAD-415 | NGS (Hi-C) |
| Unrestricted-access | 2021-12-27 | |
| JGAD000633 | NGS (RNA-seq, ChIP-seq, Hi-C) |
| Controlled-access (Type I) | 2023-01-05 | |
| JGAD001103 | NGS (RNA-seq) |
| Controlled-access (Type I) | 2026-11-05 |
Data provider
- Principal investigator
- Keisuke Tateishi
- Affiliation
- Department of Gastroenterology, The University of Tokyo
Research projects
No research projects.
Grants
| Name | Title | Project number |
|---|---|---|
KAKENHI Grant-in-Aid for Scientific Research (C) | Comprehensive biological network analysis of pancreatic cancer |
|
KAKENHI Grant-in-Aid for Scientific Research (C) | Stratification and optimization of pancreatic cancer treatment based on chromatin dynamics |
|
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
MNX1-HNF1B axis is indispensable for intraductal papillary mucinous neoplasm lineages | ||
HNF1B-driven three-dimensional chromatin structure for molecular classification in pancreatic cancers |
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Michiaki Hamada | Hamada Laboratory, Faculty of Science and Engineering, Waseda University | Japan | Construction of RNA-targeted Drug Discovery Database | 2023-01-05 – 2027-10-31 | |
| Takuya Yamamoto | Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and Nutrition | Japan | Basic research for vaccine development against gastrointestinal cancer and malignant melanoma based on the identification of novel cancer antigens | 2024-11-12 – 2027-03-31 |