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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0416-v5Release info

Latest

Research title

Elucidation of biological responses in intractable immune disorders and cancer and development of novel therapies through sequential multilevel omics analysis.

Research overview

Aims
In order to grasp the biological reactions and pathological conditions occurring in the body in more detail for diseases involving immune reactions, blood and tissue samples were used and analyzed by following the changes and changes over time for each patient. The present research will acquire and profile comprehensive parameters for each patient and explore factors related to disease conditions and treatments. Then, it will be linked to the understanding of pathology and the development of therapeutic methods through the confirmation of changes in the found molecules and the search for functions.
Methods
single-cell CITE-seq (Cellular indexing of transcriptomes and epitopes), BD Ab-seq, single-cell RNA-seq
Participants/materials
microscopic polyangiitis (MPA), systemic sclerosis (SSc), Sjögren's Syndrome (SjS), Behçet's Syndrome (BS), healthy donors
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
DRA019274NGS (CITE-seq, BD Ab-seq)
  • CITE-seq
  • CITE-seq (BD Ab-seq)
Unrestricted-access2024-09-18
E-GEAD-635NGS (CITE-seq)
  • CITE-seq
Unrestricted-access2023-08-10
E-GEAD-872NGS (CITE-seq, BD Ab-seq)
  • CITE-seq
  • CITE-seq (BD Ab-seq)
Unrestricted-access2024-10-08
DRA019233NGS (BD Ab-seq)
  • CITE-seq (BD Ab-seq)
Unrestricted-access2024-09-10
E-GEAD-867NGS (BD Ab-seq)
  • CITE-seq (BD Ab-seq)
Unrestricted-access2024-09-11
DRA020399NGS (scRNA-seq)
  • scRNA-seq
Unrestricted-access2025-04-25
E-GEAD-1051NGS (scRNA-seq)
  • scRNA-seq
Unrestricted-access2025-04-25
E-GEAD-1057single-cell spatial transcriptome
  • Single-cell spatial transcriptomics (MERSCOPE)
Unrestricted-access2025-04-30
DRA021372NGS (scRNA-seq)
  • scRNA-seq
Unrestricted-access2025-05-31
E-GEAD-1076NGS (scRNA-seq)
  • scRNA-seq
Unrestricted-access2025-06-02

Data provider

Principal investigator
Takehisa Kitazawa
Affiliation
Research Division, Chugai Pharmaceutical Co., Ltd.

Research projects

No research projects.

Grants

No grants.

Related publications

TitleDOIDataset ID
Single-cell multi-omics analysis identifies two distinct phenotypes of newly-onset microscopic polyangiitis
https://doi.org/10.1038/s41467-023-41328-0 (opens in a new tab)
Neutrophil single-cell analysis identifies a type II interferon-related subset for predicting relapse of autoimmune small vessel vasculitis
https://doi.org/10.1038/s41467-025-58550-7 (opens in a new tab)
Single-cell analysis reveals immune cell abnormalities underlying the clinical heterogeneity of systemic sclerosis
https://doi.org/10.21203/rs.3.rs-4728677/v1 (opens in a new tab)
Deciphering the Single-Cell Spatiotemporal Landscape of Tertiary Lymphoid Structures in Primary Sjögren's Syndrome
N/A
Pathological Involvement of the Classical Complement Pathway and Neutrophil Activation in Behçet's Syndrome Revealed by Single-Cell Transcriptomics and Serum Active C1s
N/A