Research ID
hum0405-v1Release info
This page is a past version (v1). The latest version is v4.
Latest version (v4)Research title
Research on the identification of cancer stem cells for peidatric and adult malignancies
Research overview
- Aims
- In recent years, "cancer stem cells" have been reported to exist in many cancers. Many reports have shown that they are the main cause of cancer recurrence. The aim of this study is to test whether cancer stem cells can be identified using patient samples. We will perform omics analysis of rare pediatric cancers by integrating genomics, transcriptomics, proteomics and metabolomics, including somatic and germline mutations, to deepen our understanding of the biological characteristics of the target disease. Based on the knowledge gained and clinical information from patients, we will conduct preclinical pharmacological studies using mouse models and in vitro models to investigate the therapeutic effects of novel therapeutic agents and novel therapeutic strategies such as cellular therapies.
- Methods
- WES, RNA-seq and Small RNA-seq
- Participants/materials
- Pediatric B-cell precursor acute lymphocytic leukemia: 69 cases
Pediatric acute myeloid leukemia: 9 cases
B-cell precursor acute lymphocytic leukemia patients who received tisagenlecleucel: 16 cases - URL
- N/A
Datasets
The list is the one this version published; each dataset's content is shown as it is now.
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000752 | NGS (Exome) NGS (RNA-seq) NGS (small RNA-seq) |
| Controlled-access (Type I) | 2023-12-26 |
Data provider
- Principal investigator
- Junko Takita
- Affiliation
- Department of Pediatrics, Graduate School of Medicine, Kyoto University
Research projects
No research projects.
Grants
| Name | Title | Project number |
|---|---|---|
Project for Promotion of Cancer Research and Therapeutic Evolution (P-PROMOTE), Japan Agency for Medical Research and Development (AMED) | Study of spatiotemporal variety of intractable pediatric cancers and development of new drugs |
|
KAKENHI Grant-in-Aid for Scientific Research (B) | Development of novel therapeutic strategies for intractable pediatric cancers based on the multi-omics information |
|
KAKENHI Grant-in-Aid for Scientific Research (A) | Integrated analysis of mechanisms of genetic susceptibility to cancer and clonal evolution in pediatric cancer |
|
KAKENHI Grant-in-Aid for Challenging Research (Exploratory) | Development of novel therapeutic strategies for pediatric solid tumor based on non-driver gene targeted approaches |
|
KAKENHI Grant-in-Aid for Challenging Research (Exploratory) | Elucidation of crosstalk between neurodevelopmental disorders and tumorigenesis and development of novel therapeutic drugs |
|
KAKENHI Grant-in-Aid for Scientific Research (A) | Clarification of spatio-temporal diversity for overcoming cancers that develop from childhood to young adulthood |
|
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
RNA-seq-based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia | ||
Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement | ||
CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL |
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Michiaki Hamada | Hamada Laboratory, Faculty of Science and Engineering, Waseda University | Japan | Construction of RNA-targeted Drug Discovery Database | 2023-01-05 – 2027-10-31 |