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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0405-v1Release info

This page is a past version (v1). The latest version is v4.
Latest version (v4)

Research title

Research on the identification of cancer stem cells for peidatric and adult malignancies

Research overview

Aims
In recent years, "cancer stem cells" have been reported to exist in many cancers. Many reports have shown that they are the main cause of cancer recurrence. The aim of this study is to test whether cancer stem cells can be identified using patient samples. We will perform omics analysis of rare pediatric cancers by integrating genomics, transcriptomics, proteomics and metabolomics, including somatic and germline mutations, to deepen our understanding of the biological characteristics of the target disease. Based on the knowledge gained and clinical information from patients, we will conduct preclinical pharmacological studies using mouse models and in vitro models to investigate the therapeutic effects of novel therapeutic agents and novel therapeutic strategies such as cellular therapies.
Methods
WES, RNA-seq and Small RNA-seq
Participants/materials
Pediatric B-cell precursor acute lymphocytic leukemia: 69 cases
URL
N/A

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000752NGS (Exome)
NGS (RNA-seq)
NGS (small RNA-seq)
  • WES
  • RNA-seq
  • miRNA-seq
Controlled-access (Type I)2023-12-26

Data provider

Principal investigator
Junko Takita
Affiliation
Department of Pediatrics, Graduate School of Medicine, Kyoto University

Research projects

No research projects.

Grants

NameTitleProject number
Project for Promotion of Cancer Research and Therapeutic Evolution (P-PROMOTE), Japan Agency for Medical Research and Development (AMED)
Study of spatiotemporal variety of intractable pediatric cancers and development of new drugs
  • JP22ama221505
KAKENHI Grant-in-Aid for Scientific Research (B)
Development of novel therapeutic strategies for intractable pediatric cancers based on the multi-omics information
  • 17H04224
KAKENHI Grant-in-Aid for Scientific Research (A)
Integrated analysis of mechanisms of genetic susceptibility to cancer and clonal evolution in pediatric cancer
  • 20H00528

Related publications

TitleDOIDataset ID
RNA-seq-based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia
https://doi.org/10.1182/bloodadvances.2023011583 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31