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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Dataset ID

JGAD000752

Type of data
NGS (Exome)
NGS (RNA-seq)
NGS (small RNA-seq)
Access criteria
Controlled-access (Type I)
Total data volume
935 GB
File formats
  • FASTQ
Research
hum0405
Date published
2023-12-26
Date modified
2023-12-26
DDBJ Search
JGAD000752 (opens in a new tab)
JGA Study
JGAS000623 (opens in a new tab)

Analysis method

WES

Materials and participants
Pediatric B-cell precursor acute lymphocytic leukemia (ICD10: C910): 64 cases
leukemia cells from peripheral blood or bone marrow fluid: 64 samples
Pediatric acute myeloid leukemia (ICD10: C920): 3 cases
whole blood or bone marrow aspirates at the time of remission or relapse: 6 samples
  • Health status
    Affected
  • Subject count
    67 (Individual)
  • Age group
    Child
Disease
Pediatric B-cell precursor acute lymphocytic leukemia (C910)
Pediatric acute myeloid leukemia (C920)
Sample description
DNAs extracted from leukemia cells
  • Tissue
    Bone marrow, Peripheral blood
  • Tumor / normal
    Tumor
Sample provider
N/A
Experimental method
WES
Target
N/A
Reagent kit
Lotus DNA Library Prep Kit
xGen Exome Research Panel
Fragmentation
Restriction enzyme reaction
Platform
MGI DNBSEQ-G400
Read type
Paired-end
Read length
150 bp
Reference genome
GRCh37
Mapping
Genomon v2.6.2
Mapping quality
Reads and variants with MAPQ< 20 or base call quality< 15 were excluded.
Coverage (depth)
129x
Data use policy
NBDC data sharing policy (JGAP000001)

RNA-seq

Materials and participants
Pediatric B-cell precursor acute lymphocytic leukemia (ICD10: C910): 69 cases
leukemia cells from peripheral blood or bone marrow fluid: 69 samples
Pediatric acute myeloid leukemia (ICD10: C920): 9 cases (5 cases revealed pediatric B-cell precursor acute lymphocytic leukemia at onset and Pediatric acute myeloid leukemia at relapse)
whole blood or bone marrow aspirates at disease onset or relapse: 15 samples
B-cell precursor acute myeloid leukemia (ICD10: C91.3): 16 cases
T cells in each patient's infusion product sorted into CD38-CD73-Tim-3-HLA-DR+ (4 marker-defined; 4MD) fraction: 13 samples
non-4MD fractions: 16 samples
  • Health status
    Affected
  • Subject count
    94 (Individual)
  • Age group
    Mixed
Disease
Pediatric B-cell precursor acute lymphocytic leukemia (C910)
Pediatric acute myeloid leukemia (C920)
B-cell precursor acute myeloid leukemia (C913)
Sample description
RNAs extracted from leukemia cells or T-cells
  • Tissue
    Bone marrow, Peripheral blood, T cell
  • Tumor / normal
    Mixed
Sample provider
N/A
Experimental method
RNA-seq
Target
N/A
Reagent kit
NEBNext Ultra II Directional RNA Library Prep Kit for Illumina
Fragmentation
Heat treatment
Platform
Illumina HiSeq X
MGI DNBSEQ-G400
Read type
Paired-end
Read length
150 bp
Reference genome
GRCh37
Mapping
Genomon v2.6.2/v2.6.3
Mapping quality
unmapped reads < 5%
Coverage (breadth)
Uniquely mapped reads: 90% (More than)
Data use policy
NBDC data sharing policy (JGAP000001)

miRNA-seq

Materials and participants
Pediatric B-cell precursor acute lymphocytic leukemia (ICD10: C910): 69 cases
leukemia cells from peripheral blood or bone marrow fluid: 69 samples
  • Health status
    Affected
  • Subject count
    69 (Individual)
  • Age group
    Child
Disease
Pediatric B-cell precursor acute lymphocytic leukemia (C910)
Sample description
RNAs extracted from leukemia cells
  • Tissue
    Bone marrow, Peripheral blood
  • Tumor / normal
    Tumor
Sample provider
N/A
Experimental method
Small RNA-seq
Target
N/A
Reagent kit
NEXTflex Small RNA Sequencing Kit v3
Fragmentation
N/A
Platform
Illumina NextSeq 550
Read type
Single-end
Read length
75 bp
Data use policy
NBDC data sharing policy (JGAP000001)