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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0088-v1Release info

This page is a past version (v1). The latest version is v2.

Latest version (v2)

Research title

Global analysis of TGF-beta family signaling in cancer cells

Research overview

Aims: To elucidate the effect and its mechanism of BMP signaling on glioma initiating cells
Methods: Target genes were identified by RNA-seq to elucidate the mechanism of regulation of glioma initiating cells by BMP. Genomic DNA was extracted from glioma initiating cells and whole genome sequencing was performed.
Participants/materials: Patient-derived glioblastoma cell lines (tumor initiating cells), 2 lines
URL: N/A

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

Cart	Dataset ID	Type of data	Platforms	Access criteria	Date published
	JGAD000077	NGS (RNA-seq)	Illumina Genome Analyzer IIx Thermo Fisher Scientific Ion Proton	Controlled-access (Type I)	2020-09-28
	JGAD000096	NGS (WGS)	Thermo Fisher Scientific Ion Proton	Controlled-access (Type I)	2020-09-28

Data provider

Principal investigator: Kohei Miyazono
Affiliation: Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo

Research projects

No research projects.

Grants

Name	Title	Project number
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas	Effects of TGF-β family on cancer microenvironment and strategies for cancer therapy	22112002
KAKENHI Grant-in-Aid for Scientific Research (B)	Roles of BMP signaling in maintenance of cell stemness	24390070
KAKENHI Grant-in-Aid for Scientific Research (S)	Transcriptional regulation by TGF-β signaling and its relation to progression of cancer	15H05774
JSPS Core-to-Core Program	Cooperative International Framework in TGF-beta Family Signaling	N/A

Related publications

Title	DOI	Dataset ID
Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells.	https://doi.org/10.1038/onc.2017.112 (opens in a new tab)	JGAD000077
Identification of a novel fusion gene HMGA2-EGFR in glioblastoma.	https://doi.org/10.1002/ijc.31179 (opens in a new tab)	JGAD000077 JGAD000096

Controlled access users

Principal investigator	Affiliation	Country/Region	Research title	Period of data use	Dataset ID
Michiaki Hamada	Hamada Laboratory, Faculty of Science and Engineering, Waseda University	Japan	Construction of RNA-targeted Drug Discovery Database	2023-01-05 – 2027-10-31	JGAD000077 JGAD000263