Skip to content
NBDC Human Database

No datasets in the cart.

Go to the cart

Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0088-v2Release info

Latest

Research title

Global analysis of TGF-beta family signaling in cancer cells

Research overview

Aims
To elucidate the effect and its mechanism of BMP signaling on glioma initiating cells
Methods
Target genes were identified by RNA-seq to elucidate the mechanism of regulation of glioma initiating cells by BMP. Genomic DNA was extracted from glioma initiating cells and whole genome sequencing was performed.
Participants/materials
Patient-derived glioblastoma cell lines (tumor initiating cells), 2 lines
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000077NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)2020-09-28
JGAD000263NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)2020-09-28
JGAD000096NGS (WGS)
  • WGS
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Kohei Miyazono
Affiliation
Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas
Effects of TGF-β family on cancer microenvironment and strategies for cancer therapy
  • 22112002
KAKENHI Grant-in-Aid for Scientific Research (B)
Roles of BMP signaling in maintenance of cell stemness
  • 24390070
KAKENHI Grant-in-Aid for Scientific Research (S)
Transcriptional regulation by TGF-β signaling and its relation to progression of cancer
  • 15H05774
KAKENHI Grant-in-Aid for Early-Career Scientists
EphA6 tyrosine kinase as a potential biomarker for BMP-based therapy in adult glioblastoma Research Project
  • 19K16735
KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Molecular mechanisms of cell differentiation and diversity by TGF-beta family members
  • 17H06326
JSPS Core-to-Core Program
Cooperative International Framework in TGF-beta Family Signaling
N/A

Related publications

TitleDOIDataset ID
Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells.
https://doi.org/10.1038/onc.2017.112 (opens in a new tab)
Identification of a novel fusion gene HMGA2-EGFR in glioblastoma.
https://doi.org/10.1002/ijc.31179 (opens in a new tab)
Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis.
https://doi.org/10.1111/cas.14187 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31