Research ID
hum0086-v2Release info
This page is a past version (v2). The latest version is v3.
Latest version (v3)Research title
Epigenomic analysis of the human placenta and endometrium constituting the fetal-maternal interface
Research overview
- Aims
- As a member of the International Human Epigenome Consortium (IHEC), we obtain high-quality standard epigenome profiles of placenta tissue from Japanese donors, and open the data to public to promote basic research in human epigenome.
- Methods
- PBAT-seq, ChIP-seq, RNA-seq, and small RNA-seq
- Participants/materials
- placenta (cytotrophoblast [normal/CT, fetal growth restriction/FGR-CT, preeclampsia/PE-CT, trisomy 18/Tri-18-CT], syncytiotrophoblast [ST], extravillous trophoblast [EVT], trophoblast stem cells [TS] derived from female/male CT, ST differentiated from TS, EVT differentiated from TS, stroma), uterus (endometrium epithelial, stroma), hydatidiform mole
Datasets
The list is the one this version published; each dataset's content is shown as it is now.
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000073 | NGS (PBAT-seq) NGS (ChIP-seq) NGS (RNA-seq) NGS (small RNA-seq) |
| Controlled-access (Type I) | 2020-09-28 | |
| JGAD000115 | NGS (PBAT-seq) NGS (ChIP-seq) NGS (RNA-seq) NGS (small RNA-seq) |
| Controlled-access (Type I) | 2020-09-28 |
Data provider
- Principal investigator
- Hiroyuki Sasaki
- Affiliation
- Medical Institute of Bioregulation, Kyushu University
Research projects
| Name | URL |
|---|---|
Core Research and Evolutional Science and Technology (CREST), International Human Epigenome Consortium (IHEC), Sasaki Team |
Grants
| Name | Title | Project number |
|---|---|---|
Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST) | Development of Fundamental Technologies for Diagnosis and Therapy Based upon Epigenome Analysis | N/A |
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
The International Human Epigenome Consortium: A blueprint for scientific collaboration and discovery. | ||
Allele-specific methylome and transcriptome analysis reveals widespread imprinting in the human placenta | ||
Derivation of Human Trophoblast Stem Cells | ||
The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells |
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Nehemiah Alvarez | De Novo Genomics Corporation | Kansas, United States | Evolutionary conservation of gene expression and epigenetic analysis of trophoblast stem cells | 2018-02-02 – 2021-03-19 | |
| Michael Roberts | Animal Sciences/ Biochemistry, University of Missouri | Missouri, United States | A comparative analysis of transcriptome data from placental cell line derived from anonymous placental cells | 2018-03-02 – 2023-08-28 | |
| Guillaume Bourque | McGill University & Genome Quebec Innovation Center, McGill University | Quebec, Canada | Epigenome Meta-Analysis Project (epiMAP) | 2018-06-07 – 2021-03-19 | |
| Martin Hirst | BC Cancer, part of the Provincial Health Services Authority | British Columbia, Canada | Epigenomic analysis of human samples | 2018-08-06 – 2022-09-05 | |
| Zhaobo Lin | School of Life Science and Technology, ShanghaiTech University | China | Comparison between reprogrammed and primary trophoblast stem cells | 2018-11-12 – 2023-07-05 | |
| Zhigang Xue | School of Medicine and Life Science, Tongji University | China | Mechanism of cell programming and embryo-gamete original disease in human embryo development. | 2018-12-17 – 2021-03-19 | |
| Todd Macfarlan | National Institute of Child Health and Human Development | Maryland, United States | Analysis of the public methylome, chromatin and transcription profiles for induced human trophoblast stem cells | 2018-12-17 – 2019-09-04 | |
| William Yeung | Department of O&G, The University of Hong Kong | China | Derivation of human expanded potential stem cells (EPSCs) from human pre-implantation embryos | 2019-02-12 – 2020-09-02 | |
| Amir Eden | Department of Cell & Developmental Biology , Institute of Life Sciences, The HebrewUniversity of Jerusalem | Israel | Consequences of DNA hypomethylation- alternative promoters | 2019-05-07 – 2023-07-13 | |
| AUSTIN SMITH | Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge | United Kingdom | Comparison of trophoblast stem cell cultures | 2019-08-19 – 2023-07-25 | |
| Thorold Theunissen | Washington University School of Medicine in St. Louis | Missouri, United States | Assessment of trophoblast fates derived from human pluripotent stem cells | 2019-12-10 – 2023-07-05 | |
| Hu Li | Department of Histoembryology, Genetics and Developmental Biology, Shanghai JiaoTong University School of Medicine | China | Derivation of Human induced Trophoblast Stem Cells from Embryonic Stem Cells | 2020-01-15 – 2024-01-30 | |
| Masatoshi Ohgushi | Lab. of Developmental System, Instutute for Frontier Life and Medical Sciences, Kyoto University | Japan | Exploring differentiaton potential of human pluripotent stem cells | 2020-03-19 – 2023-09-21 | |
| Anton Wellstein | Department of Oncology, Georgetown University School of Medicine | United States | Biomarkers to evaluate immune related adverse events (irAEs) due to treatment with immune checkpoint inhibitors (ICIs) | 2022-03-03 – 2020-09-01 | |
| Kichoon Lee | United States | Access to the National Bioscience Database Center | 2021-05-31 – 2024-12-31 | ||
| Jonghwan Kim | Department of Molecular Biosciences, University of Texas at Austin | Texas, United States | Establishment of human trophoblast stem-like cells derived from human induced pluripotent stem cells for studying human placental development | 2021-05-31 – 2023-07-05 | |
| Kenichiro Hata | Department of Maternal-Fetal Biology, National Center for Child Health and Development | Japan | Genetic and genomic analysis of fetal developmental abnormalities | 2021-06-17 – 2022-03-31 | |
| Danny Leung | Division of Life Science, The Hong Kong University of Science and Technology | Hong Kong | Defining the transcriptional regulatory roles of retrotransposons in human placenta cells. | 2021-08-11 – 2027-05-28 | |
| Kenichiro Hata | Department of Maternal-Fetal Biology, National Center for Child Health and Development | Japan | Genetic and genomic analysis of fetal developmental abnormalities | 2022-01-11 – 2022-03-31 | |
| Gianluca Ursini | Lieber Institute for Brain Development, Johns Hopkins University School of Medicine | Maryland, United States | Analysis of the transcriptional profile of Human Trophoblast Stem Cells | 2022-04-26 – 2026-12-31 | |
| Ming-an Sun | College of Veterinary Medicine, Yangzhou University | China | The activation and function of endogenous retroviruses in mammalian placentae | 2022-06-23 – 2025-01-10 | |
| Michiaki Hamada | Hamada Laboratory, Faculty of Science and Engineering, Waseda University | Japan | Construction of RNA-targeted Drug Discovery Database | 2023-01-05 – 2027-10-31 | |
| Wilfried Haerty | Research Faculty, Earlham Institute | United Kingdom | Understanding epigenetic drift in a transient reproductive tissue - defining the effects on gestation ageing and cell identity within the placenta | 2023-04-12 – 2025-02-06 | |
| Paul Robson | Genomic Medicine, The Jackson Laboratory | Connecticut, United States | Modeling extra-embryonic mesoderm lineage development with human induced pluripotent stem cells | 2024-02-08 – 2026-12-26 | |
| Masatsugu Ema | Department of Stem Cells and Human Disease Models, Shiga University of Medical Science, Research Center for Animal Life Science | Japan | Isolation and characterization of trophoblast stem cells from human placenta | 2024-08-19 – 2029-08-31 |