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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0112-v1Release info

Latest

Research title

Basic research for the establishment and characterization of human trophoblast stem cells

Research overview

Aims
To establish human trophoblast stem cells from blastocyst, and to characterize them.
Methods
PBAT-seq, ChIP-seq, RNA-seq, and miRNA-seq
Participants/materials
trophoblast stem cell (TS)
URL

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000121NGS (PBAT-seq)
NGS (ChIP-seq)
NGS (RNA-seq)
NGS (miRNA-seq)
  • PBAT-seq
  • ChIP-seq
  • RNA-seq
  • miRNA-seq
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Takahiro Arima
Affiliation
Department of Informative Genetics, Environment and Genome Research Center,Tohoku University Graduate School of Medicine

Research projects

NameURL
Core Research and Evolutional Science and Technology (CREST), International Human Epigenome Consortium (IHEC), Sasaki Team

Grants

NameTitleProject number
Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)
Epigenome analysis of cells in the placenta and endometrium forming the fetal-maternal interface
  • JP17gm0510011

Related publications

TitleDOIDataset ID
Derivation of Human Trophoblast Stem Cells
https://doi.org/10.1016/j.stem.2017.11.004 (opens in a new tab)
The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells
https://doi.org/10.1038/s41467-022-30775-w (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michael RobertsAnimal Sciences/ Biochemistry, University of MissouriMissouri, United StatesA comparative analysis of transcriptome data from placental cell line derived from anonymous placental cells2018-03-02 – 2023-08-28
Zhigang XueSchool of Medicine and Life Science, Tongji UniversityChinaMechanism of cell programming and embryo-gamete original disease in human embryo development.2018-12-17 – 2021-03-19
Todd MacfarlanNational Institute of Child Health and Human DevelopmentMaryland, United StatesAnalysis of the public methylome, chromatin and transcription profiles for induced human trophoblast stem cells2018-12-17 – 2019-09-04
Howard FineWeill Cornell MedicineNew York, United StatesRecapitulation of the trophoblast program during gliomagenesis.2018-12-18 – 2022-11-21
William YeungDepartment of O&G, The University of Hong KongChinaDerivation of human expanded potential stem cells (EPSCs) from human pre-implantation embryos2019-02-12 – 2020-09-02
Thorold TheunissenWashington University School of Medicine in St. LouisMissouri, United StatesAssessment of trophoblast fates derived from human pluripotent stem cells2019-12-10 – 2023-07-05
Hu LiDepartment of Histoembryology, Genetics and Developmental Biology, Shanghai JiaoTong University School of MedicineChinaDerivation of Human induced Trophoblast Stem Cells from Embryonic Stem Cells2020-01-15 – 2024-01-30
Jonghwan KimDepartment of Molecular Biosciences, University of Texas at AustinTexas, United StatesEstablishment of human trophoblast stem-like cells derived from human induced pluripotent stem cells for studying human placental development2021-05-31 – 2023-07-05
Danny LeungDivision of Life Science, The Hong Kong University of Science and TechnologyHong KongDefining the transcriptional regulatory roles of retrotransposons in human placenta cells.2021-08-11 – 2027-05-28
Gianluca UrsiniLieber Institute for Brain Development, Johns Hopkins University School of MedicineMaryland, United StatesAnalysis of the transcriptional profile of Human Trophoblast Stem Cells2022-04-26 – 2026-12-31
Ming-an SunCollege of Veterinary Medicine, Yangzhou UniversityChinaThe activation and function of endogenous retroviruses in mammalian placentae2022-06-23 – 2025-01-10
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31
Xinzhi ZhaoZhao lab International Peace Maternal and Child Health Hospital, School of Medicine, Shanghai Jiao Tong UniversityChinaResearch on epigenetic regulations of placenta-specific enhancers associated with preeclampsia.2022-12-19 – 2023-10-20
Paul RobsonGenomic Medicine, The Jackson LaboratoryConnecticut, United StatesModeling extra-embryonic mesoderm lineage development with human induced pluripotent stem cells 2024-02-08 – 2026-12-26
Masatsugu EmaDepartment of Stem Cells and Human Disease Models, Shiga University of Medical Science, Research Center for Animal Life ScienceJapanIsolation and characterization of trophoblast stem cells from human placenta2024-08-19 – 2026-08-31