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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0040-v1Release info

Latest

Research title

Epigenomic analysis of the human placenta

Research overview

Aims
Genome-wide identification of parent-of-origin dependent DNA methylation and gene expression in the human placenta
Methods
SNPs in human placentas and maternal blood cells were identified using Whole-Genome or Exome sequencing. Allele-specific DNA methylation and gene expression analyses were performed using the human placentas.
Participants/materials
Human placentas and maternal blood samples
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000038NGS (WGS)
NGS (Exome)
NGS (WGBS)
NGS (RNA-seq)
  • WGS
  • WES
  • WGBS
  • RNA-seq
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Takahiro Arima
Affiliation
Department of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine

Research projects

NameURL
Epigenome Analysis of Cells in the Placenta and Endometrium Forming the Fetal-maternal Interface
N/A

Grants

NameTitleProject number
Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)
Epigenome analysis of cells in the placenta and endometrium forming the fetal-maternal interface
  • JP17gm0510011

Related publications

TitleDOIDataset ID
Allele-specific methylome and transcriptome analysis reveals widespread imprinting in the human placenta
https://doi.org/10.1016/j.ajhg.2016.08.021 (opens in a new tab)
Derivation of Human Trophoblast Stem Cells
https://doi.org/10.1016/j.stem.2017.11.004 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Martin HirstBC Cancer, part of the Provincial Health Services AuthorityBritish Columbia, CanadaEpigenomic analysis of human samples2018-08-06 – 2022-09-05
Zhigang XueSchool of Medicine and Life Science, Tongji UniversityChinaMechanism of cell programming and embryo-gamete original disease in human embryo development.2018-12-17 – 2021-03-19
Jonghwan KimDepartment of Molecular Biosciences, University of Texas at AustinTexas, United StatesEstablishment of human trophoblast stem-like cells derived from human induced pluripotent stem cells for studying human placental development2021-05-31 – 2023-07-05
Gianluca UrsiniLieber Institute for Brain Development, Johns Hopkins University School of MedicineMaryland, United StatesAnalysis of the transcriptional profile of Human Trophoblast Stem Cells2022-04-26 – 2026-12-31
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31
Masatsugu EmaDepartment of Stem Cells and Human Disease Models, Shiga University of Medical Science, Research Center for Animal Life ScienceJapanIsolation and characterization of trophoblast stem cells from human placenta2024-08-19 – 2026-08-31