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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0074-v2Release info

Latest

Research title

Genome-wide association studies on Hepatitis C virus-related diseases and construction of genome database

Research overview

Aims
Genome-wide association studies on Hepatitis C virus-related diseases and construction of genome database
Methods
SNP-based genome-wide association studies
Participants/materials
1. virologic response to PEG-INF/RBV treatment
78 null virologic response (NVR)
64 virologic response (VR)
51 sustained virologic response (SVR)
2. decrease of PLT in response to PEG-IFN/RBV treatment
107 HCV patients with decrease of PLT in response to PEG-IFN/RBV treatment
196 HCV patients without decrease of PLT in response to PEG-IFN/RBV treatment
3. Hb reduction
94 HCV patients with Hb reduction
209 HCV patients without Hb reduction
4. hepatocellular carcinoma (HCC) development after eradication of HCV by IFN-based treatment
123 patients who developed HCC at ≥1 year since the end of treatment
333 patients who did not develop HCC at ≥5 years since the end of treatment
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
NHA000064GWAS for 78 NVR and 64 VR
GWAS for 78 NVR and 51 SVR
  • Genotyping by array
Unrestricted-access2018-02-27
NHA000063GWAS for 107 HCV patients with decrease of PLT in response to PEG-IFN/RBV treatment and 196 HCV patients without decrease of PLT in response to PEG-IFN/RBV treatment
  • Genotyping by array
Unrestricted-access2018-02-27
NHA000062GWAS for 94 HCV patients with Hb reduction and 209 HCV patients without Hb reduction
  • Genotyping by array
Unrestricted-access2018-02-27
NHA000074GWAS for HCC development after eradication of HCV by IFN-based treatment
123 patients who developed HCC
333 patients who did not develop HCC
  • Genotyping by array
Unrestricted-access2018-09-25

Data provider

Principal investigator
Yasuhito Tanaka
Affiliation
Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University

Research projects

No research projects.

Grants

NameTitleProject number
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan
Construction of hepatitis virus related database aiming at personalized medicine
  • H19-kanen-013
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan
Database construction and therapeuitic applications including host genetic factors for hepatitis virus related diseases
  • H22-kanen-005
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan
Genome-wide research on identification of host genetic factors to develop novel diagnostic and therapeutic methods for hepatitis.
  • JP15fk0210018
Research Program on Hepatitis, Japan Agency for Medical Research and Development (AMED)
Genome-wide research for identification of host factors associated with liver disease progression or improvement after hepatitis C virus eradication.
  • JP18fk0210001

Related publications

TitleDOIDataset ID
Genome-wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection
https://doi.org/10.1053/j.gastro.2017.01.041 (opens in a new tab)
Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C
https://doi.org/10.1038/ng.449 (opens in a new tab)
Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C
https://doi.org/10.1093/hmg/ddr249 (opens in a new tab)