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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0511-v1Release info

This page is a past version (v1). The latest version is v2.
Latest version (v2)

Research title

Identification of Molecular Markers and Elucidation of Molecular Mechanisms in Aging Using Centenarian Samples

Research overview

Aims
The purpose of this study is to analyze the total RNA in blood and single-cell RNA from centenarians, their family members, and control groups, with the aim of identifying molecular markers that increase or decrease with aging, as well as RNA molecules specific to centenarians. Additionally, the study seeks to elucidate the molecular mechanisms by which T cells, the central regulators of the immune system, change during aging.
Methods
scRNA-seq, Expression data of 16 cell surface proteins (scCITE-seq), CDR3 sequences of T-cell receptor alpha and beta chains (scTCR-seq)
Participants/materials
Dataset 1: T cells from 28 healthy individuals
Dataset 2: T cells from 6 healthy individuals stimulated for 6 hours with Phorbol 12-myristate 13-acetate (PMA) and ionomycin
URL
N/A

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000957NGS
(scRNA-seq, scTCR-seq, scCITE-seq, bulk RNA-seq)
  • scRNA-seq
  • scTCR-seq
  • scCITE-seq
  • bulk RNA-seq
Controlled-access (Type I)2026-08-03
E-GEAD-1107NGS (scRNA-seq, scTCR-seq, scCITE-seq) processed data
  • scRNA-seq
  • scTCR-seq
  • scCITE-seq
Unrestricted-access2026-07-03
E-GEAD-1108NGS (scRNA-seq, scTCR-seq, scCITE-seq) processed data
  • scRNA-seq
  • scTCR-seq
  • scCITE-seq
Unrestricted-access2026-07-03

Data provider

Principal investigator
Kosuke Hashimoto
Affiliation
Institute for Protein Research, The University of Osaka

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Elucidation of the Expansion Mechanism of Cytotoxic CD4 T Cells During Late-Stage Aging
  • 21K06135
KAKENHI Grant-in-Aid for Scientific Research (C)
Elucidation of Antigenic Memory in T Cells from Long-Lived Individuals
  • 24K09423

Related publications

TitleDOIDataset ID
CD4 CTLs in Supercentenarians: Signs of Adaptive Expansion in Healthy Aging
https://doi.org/10.1016/j.celrep.2026.117728 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.