Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0442-v1Release info

Latest

Research title

Exploratory study for stratification marker of immune checkpoint inhibitor in patients with advanced or recurrent non-small cell lung cancer

Research overview

Aims: To evaluate the performance of a prognosis prediction model based on the plasma-free amino acid concentration profile for advanced and/or recurrent non-small cell lung cancer patients who will receive anti-PD-1/PD-L1 antibody therapy
Methods: RNA-seq analysis
Participants/materials: advanced or recurrent non-small cell lung cancer patients before administering anti-PD-1/PD-L1 antibody treatment
URL: N/A

Datasets

Cart	Dataset ID	Type of data	Analysis method	Access criteria	Date published
	JGAD000805	NGS (RNA-seq)	RNA-seq	Controlled-access (Type I)	2024-08-09
	E-GEAD-883	NGS (RNA-seq)	RNA-seq	Unrestricted-access	2024-12-06

Data provider

Principal investigator: Tetsuro Sasada
Affiliation: Division of Cancer Immunotherapy, Kanagawa Cancer Center Reserach Institute

Research projects

Name	URL
Exploratory study for stratification marker of immune checkpoint inhibitor in patients with advanced or recurrent non-small cell lung cancer	N/A

Grants

Name	Title	Project number
Project Focused on Developing Key Technology for Discovering and Manufacturing Drugs for Next-Generation Treatment and Diagnosis, Japan Agency for Medical Research and Development (AMED)	Evaluation of metabolic reprogramming in tumor immune microenvironment through amino-acid profiling and its application for stratifying patients under cancer immunotherapy	JP19ae0101076

Related publications

Title	DOI	Dataset ID
Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma	https://doi.org/10.3389/fimmu.2024.1361992 (opens in a new tab)	JGAD000805 E-GEAD-883

Controlled access users

Principal investigator	Affiliation	Country/Region	Research title	Period of data use	Dataset ID
Michiaki Hamada	Hamada Laboratory, Faculty of Science and Engineering, Waseda University	Japan	Construction of RNA-targeted Drug Discovery Database	2023-01-05 – 2027-10-31	JGAD000805