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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0427-v1Release info

This page is a past version (v1). The latest version is v2.
Latest version (v2)

Research title

Establishment of cell lines derived from head and neck malignancies / Comprehensive genetic analysis and database construction for head and neck malignancies

Research overview

Aims
In the field of oncology, many researchers generally use cell lines obtained from cell banks. However, cell lines for head and neck malignancies available from cell banks are limited especially for rare-type cancers, resulting in difficulties in elucidation of biological characterization of such malignancies and establishment of therapeutic strategies. This study aimed to establish cell lines of head and neck malignancies and to examine their tumorigenic abilities in immune-deficient animals. The established cell lines will be deposited to cell banks.
Methods
Genomic DNAs extracted from peripheral blood mononuclear cells (PBMC), the primary tumor tissues, and the cell line were used for whole exome sequencing analysis.
Participants/materials
PBMC and the primary tumor tissues were collected from a patient with external auditory canal squamous cell carcinoma, and a cell line was established from the primary tumor tissues. The cell line was deposited as SCEACono2 in RIKEN BioResource Research Center (https://cellbank.brc.riken.jp/cell_bank/CellInfo/?cellNo=RCB5515&lang=En).
URL
N/A

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000775NGS (Exome)
  • WES
  • ChIP-seq
Controlled-access (Type I)2023-11-02

Data provider

Principal investigator
Takashi Nakagawa
Affiliation
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (B)
Development of novel synthesizing treatment strategy by exhaustive research on temporal bone squamous cell carcinoma
  • 18H02951
KAKENHI Grant-in-Aid for Scientific Research (B)
Elucidation of epigenetic tumor control mechanisms that determine the malignancy of squamous cell carcinoma of the temporal bone
  • 22H03236

Related publications

TitleDOIDataset ID
Establishment and characterization of a primary cell culture derived from external auditory canal squamous cell carcinoma
https://doi.org/10.1002/2211-5463.13225 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.