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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0401-v3Release info

Latest

Research title

Development of cell lines and mouse models of bone and soft tissue sarcoma to establish novel treatment

Research overview

Aims
Sarcomas are classified as rare cancers, that is, cancers with an incidence of 6/100000 patients per year. The prognosis of rare cancers, including sarcomas, is poorer than that of common cancers because of the lack of effective treatment. One of the reasons is that the biological resources of sarcomas are not sufficient for advanced research. Therefore, we are establishing several types of sarcomas recapitulating biological characteristics of them including cell lines, organoids, and mouse models in order to develop effective novel treatment against sarcomas.
Methods
RNA sequencing, Whole-exome sequencing
Participants/materials
giant cell tumor of bone: 1 case, chondrosarcoma: 2 cases, synovial sarcoma: 3 cases, histiocytic sarcoma: 1 case
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000747NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)2023-06-29
JGAD000976NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)2025-10-28
JGAD000949NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)2025-11-26
JGAD000948NGS (RNA-seq)
  • RNA-seq
Controlled-access (Type I)2025-11-27

Data provider

Principal investigator
Toru Wakamatsu
Affiliation
Department of Musculoskeletal Oncology Service, Osaka International Cancer Institute

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Early-Career Scientists
Development of sarcoma organoid panel for novel treatment
  • 20K18048
KAKENHI Grant-in-Aid for Scientific Research (C)
Development of novel therapeutic strategies for sarcomas using patient-derived organoid models
  • 23K08600

Related publications

TitleDOIDataset ID
Genetic characterization of a novel organoid from human malignant giant-cell tumor
https://doi.org/10.1016/j.jbo.2023.100486 (opens in a new tab)
Establishment of human histiocytic sarcoma organoids dependent on the SHH/YAP pathway
https://doi.org/10.1007/s13577-025-01308-6 (opens in a new tab)
Chondrosarcoma Organoids Reveal Targetable SHH Pathway Activation via PTCH1 Alterations
https://doi.org/10.21203/rs.3.rs-7826834/v1 (opens in a new tab)
Development of synovial sarcoma organoids exhibiting ferroptosis resistance despite low malic enzyme 1 expression
https://doi.org/10.21203/rs.3.rs-6871133/v1 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.