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NBDC Research ID:hum0366-v1

Release info

Latest

Title

Pathogenesis of severe acute respiratory syndrome coronavirus 2 infection (COVID-19)

Research overview

Aims: To analyze the immune response to the mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and pathophysiology of the coronavirus disease 2019 (COVID-19) and to provide insights into the clinical development.

Methods: single cell RNA-seq: Peripheral blood mononuclear cells from COVID-19 patients (with ARDS, n=8; without ARDS, n=8) and healthy controls (n=5) were analyzed by single cell RNA sequence. RNA-seq: Total RNA extracted from monocytes derived from peripheral blood mononuclear cells of healthy subjects (n=4) was analyzed by RNA sequence. ATAC-seq: DNA extracted from monocytes derived from peripheral blood mononuclear cells of healthy subjects (n=5) was analyzed by ATAC sequence.

Targets: single cell RNA-seq: patients with COVID-19 (with ARDS, n=8; without ADRS, n=8), healthy subjects (n=5) RNA-seq: healthy subjects (n=4 per person, PBMC) ATAC-seq: healthy subjects (n=4 or 5 per person, PBMC)

Datasets

Dataset ID	Access type	Type of data	Release date
E-GEAD-551	Unrestricted-access	NGS (scRNA-seq)	2023-03-16
E-GEAD-552	Unrestricted-access	NGS (RNA-seq) NGS (ATAC-seq)	2023-03-16

Data provider

Principal Investigator: Yasuhiro Kato
Affiliation: Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University

Research projects

Name	URL
No data

Grants

Name	Title	Project number
KAKENHI Grant-in-Aid for Scientific Research (S)	Pathological significance and regulation of guidance factors in neurology, immunity and metabolism.	18H05282

Related publications

Title	DOI	Datasets
Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells	https://doi.org/10.1172/jci.insight.163347	E-GEAD-551 E-GEAD-552

Controlled access users

Principal Investigator	Affiliation	Country/Region	Research title	Period of data use	Data in use (Dataset ID)
No data