Research ID

hum0365-v1Release info

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Research title

The role of gut microbiota in metabolic diseases

Aims: Diabetes is a major disease in the elderly and is responsible for an increased risk of myocardial infarction and stroke. Recently, the relationship between microbiota and diabetes has been reported in animals and humans. In this study, blood, stool, and saliva samples were collected from examinees at the University of Tokyo Health Screening Center, and 16S rRNA and metagenomic analyses were performed to determine the variation of microbiota. Furthermore, metabolome and transcriptome analyses using blood were performed to reveal changes in host metabolites and gene expression. By comparing the host- and bacteria-derived information with the metabolic parameters, we analyzed whether microbiota can be a predictor of metabolic diseases.
Methods: RNAs were extracted from peripheral blood mononuclear cells and used for CAGE-seq analysis.
Participants/materials: 298 individuals (including 103, 98, and 97 individuals from normoglycemic lean, obese, and prediabetic groups, respectively) underwent their annual health check-up at the University of Tokyo Hospital.
URL: N/A

Cart	Dataset ID	Type of data	Analysis method	Access criteria	Date published
	JGAD000695	NGS (CAGE-seq)	CAGE-seq	Controlled-access (Type I)	2023-06-12

Principal investigator: Hiroshi Ohno
Affiliation: Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences

No research projects.

Name	Title	Project number
Kanagawa Institute of Industrial Science and Technology	腸内細菌叢プロジェクト	N/A
ONO Medical Research Foundation	2型糖尿病の肝臓におけるpathogenic paradoxの解明 -肝臓特異的IRS-1･IRS-2欠損マウスを用いて-	N/A

Title	DOI	Dataset ID
Gut microbial carbohydrate metabolism contributes to insulin resistance	https://doi.org/10.1038/s41586-023-06466-x (opens in a new tab)	JGAD000695

No use of the controlled access data has been recorded.