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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0365-v1Release info

Latest
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Research title

The role of gut microbiota in metabolic diseases

Research overview

Aims
Diabetes is a major disease in the elderly and is responsible for an increased risk of myocardial infarction and stroke. Recently, the relationship between microbiota and diabetes has been reported in animals and humans. In this study, blood, stool, and saliva samples were collected from examinees at the University of Tokyo Health Screening Center, and 16S rRNA and metagenomic analyses were performed to determine the variation of microbiota. Furthermore, metabolome and transcriptome analyses using blood were performed to reveal changes in host metabolites and gene expression. By comparing the host- and bacteria-derived information with the metabolic parameters, we analyzed whether microbiota can be a predictor of metabolic diseases.
Methods
RNAs were extracted from peripheral blood mononuclear cells and used for CAGE-seq analysis.
Participants/materials
298 individuals (including 103, 98, and 97 individuals from normoglycemic lean, obese, and prediabetic groups, respectively) underwent their annual health check-up at the University of Tokyo Hospital.
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000695NGS (CAGE-seq)
  • CAGE-seq
Controlled-access (Type I)2023-06-12

Data provider

Principal investigator
Hiroshi Ohno
Affiliation
Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences

Research projects

No research projects.

Grants

NameTitleProject number
Kanagawa Institute of Industrial Science and Technology
腸内細菌叢プロジェクト
N/A
ONO Medical Research Foundation
2型糖尿病の肝臓におけるpathogenic paradoxの解明 -肝臓特異的IRS-1･IRS-2欠損マウスを用いて-
N/A

Related publications

TitleDOIDataset ID
Gut microbial carbohydrate metabolism contributes to insulin resistance
https://doi.org/10.1038/s41586-023-06466-x (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.