Title
Management of Biobank Japan and the investigation of disease biomarkers for the realization of personalized medicine Discovery of disease makers from disease cohort network
Research overview
Aims: The BioBank Japan (BBJ) is a biobank established in the Institute of Medical Science, the University of Tokyo to collect clinical information and biological materials (DNA and serum samples). It collected about 200 thousand participants of 47 diseases started in 2003 (BBJ 1st cohort), and 67 thousand participants of 38 diseases started in 2013 (BBJ 2nd cohort), both in collaboration with 12 medical centers." This project is aiming at further utilization of the materials, and clinical and genomic information managed by BBJ to contribute to precision medicine by storing, managing, and providing the materials and data, as well as identifying biomarkers associated with disease risk, prognosis, and drug sensitivity.
Methods: Asian Screening Array (ASA-24v1-0_A2) Imputation results based on TOPMed r2 (GRCh38) Quantification of 250 metabolic biomarkers by NMR spectroscopy Genome-wide association study (GWAS) for peptic ulcers proteomics analyses
Targets: BBJ 1st cohort (n = 11,716 + 180,882 + 1,285 + 2,570 + 40,907 + 3,050), BBJ 2nd cohort (n = 42,689), ToMMo (n = 49,621), UK biobank (n = 456,327), and FinnGen (n = 230,635)