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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0094-v2Release info

This page is a past version (v2). The latest version is v11.
Latest version (v11)

Research title

Genomic and epigenomic analysis of different types of cancer

Research overview

Aims
Identification of oncogenic alteration in breast cancer and lung adenocarcinoma through genomic analysis.
Methods
Whole Genome Sequencing (WGS), Whole Exome Sequencing (WES), and RNA-seq were performed with HiSeq 2000/2500.
Participants/materials
Surgically resected breast cancer tissues and paired non-tumor tissues or peripheral blood cells (as normal tissues)
WES: Triple negative breast cancer: 36 cases (including 16 cases used for WGS and 23 cases used for RNA-seq)
Lung adenocarcinoma : 43 cases
WGS: Triple negative breast cancer: 16 cases
RNA-seq: Triple negative breast cancer: 23 cases
Estrogen receptor-positive breast cancer: 17 cases
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer: 15 cases
Lung adenocarcinoma : 43 cases
URL

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000095NGS (WGS, Exome, RNA-seq)
  • WGS
  • WES
  • RNA-seq
Controlled-access (Type I)2020-09-28
JGAD000110NGS (Exome, RNA-seq)
  • WES
Controlled-access (Type I)2020-09-28
JGAD000111NGS (Exome, RNA-seq)
  • RNA-seq
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Hiroyuki Mano
Affiliation
Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Oncogenic mutations of RAC small GTPases in Human cancers
  • 26430106
Leading Advanced Projects for medical innovation, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-LEAP)
Project for novel therapeutic targets in cancer
N/A
Grant from The Princess Takamatsu Cancer Research Fund
Analysis of molecular mechanisms of oncogenic activity of RAC small GTPase
N/A

Related publications

TitleDOIDataset ID
Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency
https://doi.org/10.1371/journal.pgen.1006853 (opens in a new tab)
Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-terminal respiratory unit-type lung adenocarcinomas.
https://doi.org/10.1111/cas.13313 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
SUBHAJYOTI DERutgers Cancer Institute, Rutgers the State University of New JerseyNew Jersey, United StatesComputational method development for cancer genomic data2018-08-06 – 2023-08-10
Youping DengDepartment of Complementary & Integrative Medicine, University of Hawaii ManoaHawaii, United StatesIdentification of driver genes and somatic mutations for lung cancer diagnosis and prognosis2018-10-04 – 2029-07-10
Masaki Mandaidepartment of Gynecology and Obstetrics, Kyoto University Faculty of MediceneJapanIntegrated analyses of omics (genomics, transcriptomics, proteomics and metabolomics) associated with clinical variables for developing indivisualizedtreatment in gynecological malignancy2018-10-04 – 2025-04-14
Tetsuya SatoResearch Laboratory, H.U. Group Research Institute G.K.JapanSearch for Lynch syndrome colorectal cancer-related genes using contolled-access clinical sequence data2019-08-05 – 2021-01-28
Kouya ShiraishiDivision of Genome Biology, National Cancer Research InstituteJapanElucidation of immune-system networks between host and tumor based on genomic analysis2019-08-05 – 2029-03-31
Ruping SunDepartment of laboratory medicine and pathology, University of MinnesotaMinnesota, United StatesAccounting for Copy Number States in Quantifying Tumor Heterogeneity2020-03-19 – 2023-01-16
Masanori AritaBioinformation and DDBJ Center, National Institute of GeneticsJapanProvision of processed JGA data analyzed by DDBJ Center and NBDC2021-10-07 – 2030-03-31
Hirofumi NakaokaDepartment of Cancer Genome Research, Sasaki InstituteJapanGenetic analysis of lung cancer2022-08-17 – 2026-07-23
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31
Nobuyuki KakiuchiThe Hakubi Center for Advanced Research, Kyoto UniversityJapanComprehensive analysis of genetic aberrations in solid tumors2023-04-06 – 2028-03-31
Jin WangDepartment of Musculoskeletal Oncology, Sun Yat-sen University Cancer CenterChinaGenomics study of desmoid tumor2023-09-06 – 2029-12-30
Charles SwantonThe Francis Crick InstituteUnited KingdomStudying lung cancer evolution in smokers and never-smokers2024-09-03 – 2026-05-07
Mayumi KamadaLaboratory of Life Sciences Information Design, Department of Data Science, School of Frontier Engineering, Kitasato UniversityJapanInvestigation of Gene Expression Profiles in Lung Cancer: Biological Characteristics and Biomarker Development for Diagnosis and Therapy2025-12-08 – 2028-03-31