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NBDC Research ID:hum0086-v3
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Research title

Epigenomic analysis of the human placenta and endometrium constituting the fetal-maternal interface

Research overview

Aims: As a member of the International Human Epigenome Consortium (IHEC), we obtain high-quality standard epigenome profiles of placenta tissue from Japanese donors, and open the data to public to promote basic research in human epigenome.

Methods: PBAT-seq, ChIP-seq, RNA-seq, and small RNA-seq

Targets: placenta (cytotrophoblast [normal/CT, fetal growth restriction/FGR-CT, preeclampsia/PE-CT, trisomy 18/Tri-18-CT], syncytiotrophoblast [ST], extravillous trophoblast [EVT], trophoblast stem cells [TS] derived from female/male CT, ST differentiated from TS, EVT differentiated from TS, stroma), uterus (endometrium epithelial, stroma), hydatidiform mole

Datasets

Dataset ID
Access type
Type of data
Release date
JGAD000073Controlled-access (Type I)NGS (PBAT-seq) NGS (ChIP-seq) NGS (RNA-seq) NGS (small RNA-seq)2020-09-28
JGAD000115Controlled-access (Type I)NGS (PBAT-seq) NGS (ChIP-seq) NGS (RNA-seq) NGS (small RNA-seq)2020-09-28

Data provider

    Principal investigator
    Hiroyuki Sasaki
    Name
    Medical Institute of Bioregulation, Kyushu University

Research projects

Name
URL
Core Research and Evolutional Science and Technology (CREST), International Human Epigenome Consortium (IHEC), Sasaki Teamhttps://crest-ihec.jp/english/index.html

Grants

Name
Title
Project number
Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)Development of Fundamental Technologies for Diagnosis and Therapy Based upon Epigenome Analysis

    Related publications

    Title
    DOI
    		Dataset ID
    The International Human Epigenome Consortium: A blueprint for scientific collaboration and discovery.https://doi.org/10.1016/j.cell.2016.11.007
    Allele-specific methylome and transcriptome analysis reveals widespread imprinting in the human placentahttps://doi.org/10.1016/j.ajhg.2016.08.021
    Derivation of Human Trophoblast Stem Cellshttps://doi.org/10.1016/j.stem.2017.11.004
    The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cellshttps://doi.org/10.1038/s41467-022-30775-w

    Controlled access users

    Principal Investigator
    Affiliation
    Country/Region
    Research title
    Period of data use
    		Dataset ID
    Eden AmirThe HebrewUniversity of JerusalemIsraelConsequences of DNA hypomethylation- alternative promoters2019-05-07—2023-07-13
    SMITH AUSTINUniversity of CambridgeUnited KingdomComparison of trophoblast stem cell cultures2019-08-19—2023-07-25
    Leung DannyThe Hong Kong University of Science and TechnologyHKGDefining the transcriptional regulatory roles of retrotransposons in human placenta cells.2021-08-11—2027-05-28
    Bourque GuillaumeMcGill UniversityCanadaEpigenome Meta-Analysis Project (epiMAP)2018-06-07—2021-03-19
    Haerty WilfriedEarlham InstituteUnited KingdomUnderstanding epigenetic drift in a transient reproductive tissue - defining the effects on gestation ageing and cell identity within the placenta2023-04-12—2025-02-06
    Hamada MichiakiWaseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05—2027-10-31
    Kim JonghwanUniversity of Texas at AustinUSAEstablishment of human trophoblast stem-like cells derived from human induced pluripotent stem cells for studying human placental development2021-05-31—2023-07-05
    Lee Kichoon(Filled by DDBJ)USAAccess to the National Bioscience Database Center2021-05-31—2025-01-01
    Li HuShanghai JiaoTong University School of MedicineChinaDerivation of Human induced Trophoblast Stem Cells from Embryonic Stem Cells2020-01-15—2024-01-30
    Lin ZhaoboShanghaiTech UniversityChinaComparison between reprogrammed and primary trophoblast stem cells2018-11-12—2023-07-05
    Hirst MartinBC Cancer, part of the Provincial Health Services AuthorityCanadaEpigenomic analysis of human samples2018-08-06—2022-09-05
    Sun Ming-anYangzhou UniversityChinaThe activation and function of endogenous retroviruses in mammalian placentae2022-06-23—2025-01-10
    Ohgushi MasatoshiInstutute for Frontier Life and Medical Sciences, Kyoto UniversityJapanExploring differentiaton potential of human pluripotent stem cells2020-03-19—2023-09-21
    Alvarez NehemiahDe Novo Genomics CorporationUSAEvolutionary conservation of gene expression and epigenetic analysis of trophoblast stem cells2018-02-02—2021-03-19
    Robson PaulThe Jackson LaboratoryUSAModeling extra-embryonic mesoderm lineage development with human induced pluripotent stem cells2024-02-08—2026-12-26
    Ema MasatsuguShiga University of Medical Science, Research Center for Animal Life ScienceJapanIsolation and characterization of trophoblast stem cells from human placenta2024-08-19—2026-09-01
    Roberts MichaelUniversity of MissouriUSAA comparative analysis of transcriptome data from placental cell line derived from anonymous placental cells2018-03-02—2023-08-28
    Hata KenichiroNational Center for Child Health and DevelopmentJapanGenetic and genomic analysis of fetal developmental abnormalities2021-06-17—2022-03-31
    Theunissen ThoroldWashington University School of Medicine in St. LouisUSAAssessment of trophoblast fates derived from human pluripotent stem cells2019-12-10—2023-07-05
    Macfarlan ToddNational Institute of Child Health and Human DevelopmentUSAAnalysis of the public methylome, chromatin and transcription profiles for induced human trophoblast stem cells2018-12-17—2019-09-04
    Ursini GianlucaLieber Institute for Brain DevelopmentUSAAnalysis of the transcriptional profile of Human Trophoblast Stem Cells2022-04-26—2026-12-31
    Yeung WilliamThe University of Hong KongChinaDerivation of human expanded potential stem cells (EPSCs) from human pre-implantation embryos2019-02-12—2020-09-02
    Xue ZhigangTongji UniversityChinaMechanism of cell programming and embryo-gamete original disease in human embryo development.2018-12-17—2021-03-19