Skip to content
NBDC Human Database

No datasets in the cart.

Go to the cart

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0074-v1Release info

This page is a past version (v1). The latest version is v2.
Latest version (v2)

Research title

Genome-wide association studies on Hepatitis C virus-related diseases and construction of genome database

Research overview

Aims
Genome-wide association studies on Hepatitis C virus-related diseases and construction of genome database
Methods
SNP-based genome-wide association studies
Participants/materials
1. virologic response to PEG-INF/RBV treatment
78 null virologic response (NVR)
64 virologic response (VR)
51 sustained virologic response (SVR)
2. decrease of PLT in response to PEG-IFN/RBV treatment
107 HCV patients with decrease of PLT in response to PEG-IFN/RBV treatment
196 HCV patients without decrease of PLT in response to PEG-IFN/RBV treatment
3. Hb reduction
94 HCV patients with Hb reduction
209 HCV patients without Hb reduction
URL
N/A

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
NHA000064GWAS for 78 NVR and 64 VR
GWAS for 78 NVR and 51 SVR
  • Genotyping by array
Unrestricted-access2018-02-27
NHA000063GWAS for 107 HCV patients with decrease of PLT in response to PEG-IFN/RBV treatment and 196 HCV patients without decrease of PLT in response to PEG-IFN/RBV treatment
  • Genotyping by array
Unrestricted-access2018-02-27
NHA000062GWAS for 94 HCV patients with Hb reduction and 209 HCV patients without Hb reduction
  • Genotyping by array
Unrestricted-access2018-02-27

Data provider

Principal investigator
Yasuhito Tanaka
Affiliation
Department of Virology, Graduate School of Medical Sciences, Nagoya City University

Research projects

No research projects.

Grants

NameTitleProject number
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan
Construction of hepatitis virus related database aiming at personalized medicine
  • H19-kanen-013
Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan
Database construction and therapeuitic applications including host genetic factors for hepatitis virus related diseases
  • H22-kanen-005

Related publications

TitleDOIDataset ID
Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C
https://doi.org/10.1038/ng.449 (opens in a new tab)
Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C
https://doi.org/10.1093/hmg/ddr249 (opens in a new tab)