Research ID
hum0053-v2Release info
Latest
Research title
Identification of new molecular targets with profiling of malignant mesothelioma
Research overview
- Aims
- Malignant pleural mesothelioma which is associated with asbestos exposure is highly aggressive and refractory to conventional therapeutic modalities. The aim of this study is identification of new targets for molecular target therapy by next generation sequencing and application of the genomic data to new diagnostic and therapeutic strategies for malignant pleural mesothelioma patients.
- Methods
- Exome: We extracted genomic DNAs from surgical specimens or established mesothelioma cell lines from Japanese malignant pleural mesothelioma patients. We also extracted control DNAs from peripheral blood of the same patients. We performed whole exome sequencing using these DNAs.
WGS: We extracted genomic DNAs from established mesothelioma cell lines from Japanese malignant pleural mesothelioma patients. We sequenced those genomic DNAs using 10X Genomics sequencing technologies, and analyzed genomic structural variations. - Participants/materials
- 38 Malignant pleural mesothelioma patients (including 12 established mesothelioma cell lines)
- URL
- N/A
Datasets
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD000062 | NGS (Exome) |
| Controlled-access (Type I) | 2020-09-28 | |
| JGAD000256 | NGS (Exome) |
| Controlled-access (Type I) | 2020-09-28 |
Data provider
- Principal investigator
- Takashi Nakano
- Affiliation
- Hyogo College of Medicine, Division of Respiratory Medicine
Research projects
| Name | URL |
|---|---|
Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT) |
Grants
| Name | Title | Project number |
|---|---|---|
Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT), Japan Agency for Medical Research and Development (AMED) | Development of therapeutic modalities against intractable cancers via identification of new therapeutic targets with molecular profiling (Identification of new molecular targets with profiling of malignant mesothelioma) |
|
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED) | Identification of novel molecular targets by comprehensive understanding of genomic abnormalities and metabolic and cellular characteristics of malignant mesothelioma |
|
Related publications
| Title | DOI | Dataset ID |
|---|---|---|
Integrative molecular characterization of malignant pleural mesothelioma. |
Controlled access users
| Principal investigator | Affiliation | Country/Region | Research title | Period of data use | Dataset ID |
|---|---|---|---|---|---|
| Kouya Shiraishi | Division of Genome Biology, National Cancer Research Institute | Japan | Elucidation of immune-system networks between host and tumor based on genomic analysis | 2019-08-05 – 2029-03-31 | |
| Masanori Arita | Bioinformation and DDBJ Center, National Institute of Genetics | Japan | Provision of processed JGA data analyzed by DDBJ Center and NBDC | 2021-10-07 – 2030-03-31 |