Research ID
hum0574-v2Release info
Latest
Research title
Research on constructing a genome analysis database for malignant tumors
Research overview
- Aims
- To build a comprehensive genome analysis database for malignant tumors and to analyze the pathology of malignant tumors from multiple angles, thereby clarifying the relationship between genome information and clinical course, developing diagnostic techniques using artificial intelligence, and developing new treatments.
- Methods
- Total RNA extracted from fresh frozen tissues using the RNeasy Plus Universal Mini Kit was used for RNA sequencing.
Genomic DNA extracted from the FFPE and from fresh-frozen tissues using the Maxwell RSC DNA FFPE Kit and Maxwell RSC Tissue DNA Kit, respectively was used for whole exome sequencing.
Genomic DNA extracted from fresh frozen tissues using the Maxwell 16 LEV Blood DNA Kit was used for whole genome sequencing. - Participants/materials
- Two patients with rectal cancer (one with POLE mutation-positive, the other one with POLE mutation-negative), 4 patients with histologically confirmed gastric adenocarcinoma who were carriers of germline pathogenic variants (GPVs) in BRCA1/2 detected by germline BRCA1/2 testing,
32 patients with colorectal cancer who underwent curative surgical resection. - URL
- N/A
Datasets
| Cart | Dataset ID | Type of data | Analysis method | Access criteria | Date published |
|---|---|---|---|---|---|
| JGAD001063 | NGS (RNA-seq) |
| Controlled-access (Type I) | 2026-07-27 | |
| JGAD001064 | NGS (Exome) |
| Controlled-access (Type I) | 2026-07-27 | |
| JGAD001079 | NGS (WGS) |
| Controlled-access (Type I) | 2026-11-06 |
Data provider
- Principal investigator
- Yoshifumi Shimada
- Affiliation
- Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
- Principal investigator
- Hiroshi Ichikawa
- Affiliation
- Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
Research projects
No research projects.
Grants
| Name | Title | Project number |
|---|---|---|
KAKENHI Grant-in-Aid for Scientific Research (C) | Elucidation of the molecular mechanisms underlying the response to chemoradiotherapy in rectal cancer through analysis of dynamic immune responses |
|
KAKENHI Grant-in-Aid for Scientific Research (C) | Molecular Characteristics and Clinical Outcome of Gastric Cancer with Germline Mutation in Homologous Recombination Repair Genes |
|
Research Grant from Denka Company Limited | Research on Cancer Gene Mutations and Their Association with Treatment Selection in Japanese Patients |
|
Research Grant from Denka Company Limited | Translational Research on Cancer Gene Mutations and Their Clinical Application to Treatment Selection in Japanese Patients |
|
Research Grant from Denka Company Limited | Translational Research on Cancer Gene Mutations and Their Clinical Application to Treatment Selection in Japanese Patients: Evaluation of Genomic Data Management Methods in Cancer Genetic Testing |
|
Research Grant from Denka Company Limited | Clinical Performance Evaluation of Next-Generation Sequencing-Based Genetic Testing Using the CANCERPLEX-JP® 435-Gene Panel for Identifying Therapeutic Targets in Cancer |
|
Research Grant from Niigata Prefecture | Research on the Development of an Infrastructure for Cancer Genomic Medicine Using Next-Generation Sequencing |
|
Related publications
No related publications.
Controlled access users
No use of the controlled access data has been recorded.