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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0544-v1Release info

Latest

Research title

Research on human spermatogenesis and establishment of iPS cells

Research overview

Aims
The testis is known to be the tissue with the fastest evolutionary rate, and its properties vary greatly between species. Spermatogonial stem cells (SSCs) are the stem cells responsible for spermatogenesis in the adult testis. Previous research using monkeys has revealed that the SSC system in primates differs significantly from that in mice. This study aims to understand the primate SSC system and investigate the causes of human male infertility.
Methods
Testes were dispersed with collagenase 4 and trypsin. SSEA4-positive cells were collected by FACS and used for single-cell bisulfite-seq analysis.
Participants/materials
Normal testes from obstructive azoospermia
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001032NGS (scWGBS)
  • scWGBS
Controlled-access (Type I)2026-03-11

Data provider

Principal investigator
Toshiaki Watanabe
Affiliation
Center for Regenerative Medicine, National Center for Child Health and Development

Research projects

NameURL
Primate/human germ cell research project/Watanabe group

Grants

NameTitleProject number
Precursory Research for Innovative Medical care (PRIME), Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED)
Study of the establishment of DNA methylation during primate germ cell development
  • JP22gm6310010

Related publications

TitleDOIDataset ID
Establishment of DNA methylation during primate germ cell development
https://doi.org/10.1038/s41467-026-71405-z (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.