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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0542-v1Release info

Latest

Research title

Studies on establishment of germline DNA methylation

Research overview

Aims
Previous studies using monkeys have revealed the timing and mechanism of DNA methylation establishment in primate germ cells. The purpose of this study is to understand the establishment of DNA methylation in human testicular and ovarian germ cells. This study will advance our understanding of human germ cell development and contribute to the prevention of abnormal gamete DNA methylation and the development of infertility treatments.
Methods
single-cell whole genome bisulfite-sequencing
Participants/materials
Three testicular cancer patients
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD001031NGS (scWGBS)
  • scWGBS
Controlled-access (Type I)2026-03-10

Data provider

Principal investigator
Toshiaki Watanabe
Affiliation
Center for Regenerative Medicine, National Center for Child Health and Development

Research projects

NameURL
Primate/human germ cell research project/Watanabe group

Grants

NameTitleProject number
Precursory Research for Innovative Medical care (PRIME), Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED)
Study of the establishment of DNA methylation during primate germ cell development
  • JP22gm6310010

Related publications

TitleDOIDataset ID
Establishment of DNA methylation during primate germ cell development
https://doi.org/10.1038/s41467-026-71405-z (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.