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NBDC Research ID:hum0543-v1

Release info

Latest

Title

Research on Large-Scale Genomic Structural Abnormalities and Cancer Genome Evolution in Colorectal Cancer

Research overview

Aims: Although colorectal cancer is one of the tumors with the best-understood carcinogenesis mechanisms, proposed as a multistage process where multiple cancer genes and tumor suppressor gene abnormalities accumulate in normal colonic mucosal epithelium, leading to progression through adenoma, mucosal carcinoma, and invasive carcinoma, the mechanisms by which large-scale genomic structural abnormalities, such as whole-genome duplication, contribute to carcinogenesis remain poorly understood. This study aims to estimate the occurrence of chromosomal structural abnormalities during the multistage carcinogenesis process. It seeks to elucidate the relationship between cancer heterogeneity and the evolution of cancer clones, as well as the association with tumor progression and metastasis.

Methods: whole genome sequencing

Targets: 62 patients with colorectal cancer

Datasets

	Dataset ID	Access type	Type of data	Release date
	JGAD001015	Controlled-access (Type I)	NGS (WGS)	2026-06-11

Data provider

Principal Investigator: Shinichi Yachida
Affiliation: Department of Cancer Genome Informatics, Graduate School of Medicine, Osaka University

Research projects

Name	URL
No data

Grants

Name	Title	Project number
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)	Integrated Analysis of Large-Scale Japanese Cancer Genomic, Multi-Omics, and Clinical Data to Advance Precision Prevention and Genomic Medicine through International Collaboration	JP25ck0106800
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)	Deciphering Gut Microenvironmental Dynamics Associated with Colorectal Carcinogenesis in High-Risk Individuals and Developing Personalized Strategies for Colorectal Cancer Prevention	JP22ck0106546
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)	Development of Personalized Colorectal Cancer Prevention Strategies Based on Integrated Characterization of the Gut Ecosystem Using Stool and Biopsy Specimens from Ultra-High-Risk Individuals	JP25ck0106799
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)	Establishment of a Nationwide Whole-Genome Medicine Platform and Development of Innovative Therapeutics for Refractory Gastrointestinal Cancers through Comprehensive Integration of Whole-Genome Sequencing and Clinical Data	JP25ck0106874
Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)	Large-Scale International Collaborative Research Leveraging Integrated Cancer Genomic and Multi-Omics Analyses in Japanese Populations to Advance Innovative Prevention, Diagnosis, and Treatment	JP26ck0106162
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)	Development of Gut Microbiome-Based Predictive Biomarkers for Adverse Events Associated with Anticancer Therapies	JP21cm0106477
Project for Promotion of Cancer Research and Therapeutic Evolution (P-PROMOTE), Japan Agency for Medical Research and Development (AMED)	Elucidating the Etiology of Early-Onset Colorectal Cancer through Integrated Analyses of Diet, Gut Microbiota, and Inflammation, and Developing Risk Assessment and Early Detection Strategies	JP25ama221430
Research Program on the challenges of Global Health issues, Japan Agency for Medical Research and Development (AMED)	Disease-Oriented Research on Infection-Associated Cancers under the Framework of the U.S.-Japan Cooperative Medical Sciences Program	JP23jk0210009
Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)	Elucidating the Impact of Individual and Sex-Specific Variations in the Local Intestinal Microbiome on the Colorectal Pre-Disease State and Developing Microbiome-Based Preventive Strategies	JP26gm2010009
Advanced International Collaborative Research Program - Adopting Sustainable Partnerships for an Innovative Research Ecosystem (ASPIRE), Japan Agency for Medical Research and Development (AMED)	The ELDER Study: Defining the Timing of Cancer Initiation through High-Resolution Quantification of Organ-Specific Aging	JP26jf0126022
KAKENHI Grant-in-Aid for Scientific Research (B)	Metagenomic Characterization of Familial Adenomatous Polyposis and Its Application to Elucidating Mechanisms of Colorectal Tumor Initiation and Progression	20H03662
KAKENHI Grant-in-Aid for Scientific Research (B)	Characterization of Gut Microenvironmental Alterations Along the Serrated Pathway of Colorectal Tumorigenesis	23H02892

Related publications

Title	DOI	Datasets
Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer	https://doi.org/10.52843/cassyni.86lmq6	JGAD001015

Controlled access users

Principal Investigator	Affiliation	Country/Region	Research title	Period of data use	Data in use (Dataset ID)
No data