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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0531-v1Release info

Latest

Research title

Identification of Therapeutic Target Molecules in Urological Tumors by Whole-Genome Sequencing

Research overview

Aims
Urological malignancies, including prostate, kidney, and bladder cancers, are increasing, with somatic genomic alterations playing a key role. Traditional analyses are insufficient to fully explain tumorigenesis. Using next-generation sequencing, this study aims to comprehensively identify tumor-specific alterations and novel therapeutic targets through multi-layered genomic analysis.
Methods
Targeted panel analysis using the NOIR-SS method was performed on formalin-fixed paraffin-embedded (FFPE) tumor tissues from 15 patients with advanced urothelial carcinoma and identified somatic mutations. Plasma cfDNA (50 samples) from the same patients was analyzed using a tumor-informed approach, focusing on the mutations identified in the corresponding tumor tissues.
Participants/materials
Advanced urothelial carcinoma 15 cases
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000978NGS (Amplicon-seq)
  • RNA Amplicon-seq
Controlled-access (Type I)2025-11-12

Data provider

Principal investigator
Yoichi Fujii
Affiliation
Department of Urology, The University of Tokyo Graduate School of Medicine

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Quantification of ctDNA and Identification of Background Factors in Clear Cell Renal Cell Carcinoma Using NOIR-SS
  • 23K08731

Related publications

TitleDOIDataset ID
High Sensitivity ctDNA Analysis Using a Novel Panel and NOIR-SS Technology for Monitoring Advanced Urothelial Carcinoma
https://doi.org/10.1002/cam4.72045 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.