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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0521-v1Release info

Latest

Research title

Elucidation of Molecular Mechanisms of Cancer Immunity

Research overview

Aims
This study aims to clarify tumor immunity in uterine cancer. In particular, we aim to describe the characteristics of B cells and T cells in the tumor microenvironment of uterine cancer and to deepen our understanding of them.
Methods
Uterine specimens were digested with enzymes to separate CD45+ lymphocytes using MACS (Magnetic cell sorting). Subsequently, CD19+ B cells and CD3+ T cells were separated using FACS (Fluorescence-activated cell sorting). Isolated B and T cells were then analyzed using single-cell RNA-seq, single-cell BCR-seq, single-cell TCR-seq, and CITE-seq.
Participants/materials
tumor tissues of 10 uterine cancer patients, normal uterine tissue from 1 patient with hereditary breast and ovarian cancer syndrome
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000969NGS (scRNA-seq, scBCR-seq, scTCR-seq, CITE-seq)
  • scRNA-seq
  • scBCR-seq
  • scTCR-seq
  • CITE-seq
Controlled-access (Type I)2025-09-01
E-GEAD-1121NGS (scRNA-seq, scBCR-seq, scTCR-seq, CITE-seq)
  • scRNA-seq
  • scBCR-seq
  • scTCR-seq
  • CITE-seq
Unrestricted-access2025-08-25

Data provider

Principal investigator
Hideki Ueno
Affiliation
Department of Immunology, Graduate School of Medicine, Kyoto University

Research projects

No research projects.

Grants

No grants.

Related publications

TitleDOIDataset ID
Oligoclonal expansion of IgG+ B cells along with Tfh cell response is associated with a better outcome in endometrial cancer
https://doi.org/10.1093/intimm/dxaf049 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31