hum0495-v1Release info

Precision medicine for preventing stroke in patients with atrial fibrillation

Aims

Atrial fibrillation (AF) is the most prevalent arrhythmia in the world and can cause serious complications such as stroke or heart failure. Paroxysmal atrial fibrillation (PAF), a subtype of AF, accounts for approximately 25% of AF cases and is estimated to affect approximately 30 million people worldwide. Despite extensive genetic research on AF, the genetic factors involved in PAF in East Asian populations remain unidentified. The aim of our study is to identify genetic factors associated with PAF in the Japanese population, contributing to our understanding of the genetic architecture of AF in Japanese populations.

Methods

We performed whole exome sequencing and processed the sequencing data according to the best practices described in the Genome Analysis Toolkit (GATK). We also performed gene-based association tests, specifically burden tests, sequence kernel association test (SKAT), and SKAT-O.

Participants/materials

1,176 PAF patients and 1,172 non-PAF patients

URL

N/A

Principal investigator

Toshihiro Tanaka

Affiliation

Department of Human Genetics and Disease Diversity, Institute of Science Tokyo

No research projects.