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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0495-v2Release info

Latest

Research title

Precision medicine for preventing stroke in patients with atrial fibrillation

Research overview

Aims
Atrial fibrillation (AF) is common in older adults, and AF-associated ischemic stroke can lead to reduced quality of life or a bedridden state. This study will collect multi-layered data, including genetic, clinical, physiological, and electrocardiographic information, from AF patients and healthy controls, and will develop AI-based algorithms to stratify the risks of AF onset and stroke. Our goal is to establish a foundation applicable to primary screening through health checkups and IoT devices, personalized preemptive medicine, and drug discovery or new drug development.
Methods
[hum0495.v1.gwas.v1] We performed whole exome sequencing and processed the sequencing data according to the best practices described in the Genome Analysis Toolkit (GATK). We also performed gene-based association tests, specifically burden tests, sequence kernel association test (SKAT), and SKAT-O.
[JGAS000866] Genotyping was performed using SNP arrays, followed by imputation with the 1000 Genomes reference panel, and GWAS was performed using covariate-adjusted logistic regression.
Participants/materials
1,176 PAF patients and 1,172 non-PAF patients
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
NHA000199GWAS for PAF using whole exome sequencing data
  • WES + Genotyping by array
Unrestricted-access2025-02-13
JGAD001009GWAS for PAF
  • Genotyping by array (GWAS)
Controlled-access (Type I)2026-03-03

Data provider

Principal investigator
Toshihiro Tanaka
Affiliation
Department of Human Genetics and Disease Diversity, Institute of Science Tokyo

Research projects

No research projects.

Grants

NameTitleProject number
Project for Medical Device and Healthcare, Japan Agency for Medical Research and Development (AMED)
Establishment of intelligent infrastructure of prevention and detection of atrial fibrillation
  • JP21he2102002

Related publications

TitleDOIDataset ID
Rare genetic variants involved in increased risk of paroxysmal atrial fibrillation in a Japanese population
https://doi.org/10.1038/s41598-025-97794-7 (opens in a new tab)
Genetic variants and polygenic risk scores associated with paroxysmal atrial fibrillation in the Japanese population
https://doi.org/10.1371/journal.pone.0344360 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.