Skip to content
NBDC Human Database

No datasets in the cart.

Go to the cart

Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0435-v1Release info

Latest

Research title

Investigation of a method for generating cells for regenerative medicine using comprehensive nucleic acid analysis of iPS cell-derived cardiomyocytes

Research overview

Aims
Regenerative medicine for heart failure is expected to restore cardiac function by using human iPS cells (hiPSCs). In our laboratory, it was shown that transplantation of cardiomyocytes (CMs) derived from hiPSCs into a pig model of myocardial infarction improves the disease condition. However, the instability of differentiation efficiency and tumorigenicity after transplantation are still issues to be resolved. We attempt to identify and analyze the genes and DNA methylation associated with the induction of differentiation of hiPSCs into CMs to achieve stable induction of CMs differentiation. Furthermore, we aim to analyze genes involved in tumorigenesis in CMs, and to develop a predictive marker for tumorigenesis to ensure the safety of cells before transplantation.
Methods
Cardiomyocytes were induced from human iPS cells and gene expression was analyzed by single cell RNA-seq.
Participants/materials
Cardiomyocytes differentiated from human iPS cells established from peripheral blood cells of a healthy donor
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000795NGS (scRNA-seq)
  • scRNA-seq
Controlled-access (Type I)2024-03-18

Data provider

Principal investigator
Shigeru Miyagawa
Affiliation
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine

Research projects

No research projects.

Grants

NameTitleProject number
Research Center Network for Realization of Regenerative Medicine, Japan Agency for Medical Research and Development (AMED)
Center for the development of myocardial regenerative treatments using iPS cells
  • JP20bm0204003

Related publications

TitleDOIDataset ID
Pre-clinical evaluation of the efficacy and safety of human induced pluripotent stem cell-derived cardiomyocyte patch
https://doi.org/10.1186/s13287-024-03690-8 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.