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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0419-v4Release info

Latest

Research title

Application of organoid culture system of human gastrointestinal and thoracic cancer in genome medicine

Research overview

Aims
We generated organoids derived from gastrointestinal cancer and intra-thoracic malignancy, and selected effective anticancer agents and molecular targeted drugs based on genome analysis. In addition, we analyze their antitumor effects and construct a drug evaluation system for personalized medicine. Furthermore, by genetically modifying normal lung organoids, we elucidate the molecular mechanisms involved in the carcinogenesis of lung cancer.
Methods
Whole exome sequencing and RNA sequencing analysis
Participants/materials
Organoids established from patients with pulmonary large-cell neuroendocrine carcinoma, a patient with mucus-producing solid-dominant adenocarcinoma of lung and a patient with pulmonary adenocarcinoma harboring EML4-ALK variant 3, organoids established from patients with esophageal cancer
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000771NGS (Exome)
  • WES
Controlled-access (Type I)2024-04-24
JGAD000783NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)2024-05-09
JGAD000794NGS (Exome, RNA-seq)
  • WES
  • RNA-seq
Controlled-access (Type I)2024-06-18
JGAD000884NGS (Exome)
  • WES
Controlled-access (Type I)2025-04-18

Data provider

Principal investigator
Takuya Fukazawa
Affiliation
Department of General Surgery, Kawasaki Medical School

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Elucidation of mechanism of carcinogenesis and progression in lung squamous cell carcinoma with organoid technology
  • 19K07699
KAKENHI Grant-in-Aid for Scientific Research (B)
Elucidation of the molecular pathogenesis and carcinogenic mechanisms of pulmonary neuroendocrine tumors using organoids
  • 22H03164

Related publications

TitleDOIDataset ID
Patient-derived tumoroid models of pulmonary large-cell neuroendocrine carcinoma: A promising tool for personalized medicine and developing novel therapeutic strategies
https://doi.org/10.1016/j.canlet.2024.216816 (opens in a new tab)
Establishment and characterization of novel high mucus-producing lung tumoroids derived from a patient with pulmonary solid adenocarcinoma
https://doi.org/10.1007/s13577-024-01060-3 (opens in a new tab)
Transforming tumoroids derived from ALK-positive pulmonary adenocarcinoma to squamous cell carcinoma in vivo
https://doi.org/10.1007/s13577-024-01085-8 (opens in a new tab)
Establishment and characterization of novel patient-derived esophageal tumoroids with long-term cultivability
https://doi.org/10.1007/s13577-025-01206-x (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.