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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0340-v1Release info

Latest

Research title

Comprehensive genomic analysis using next-generation sequencer for pediatric solid tumor cases

Research overview

Aims
Compared to adult cancer, pediatric cancer has an extremely small number of patients and a wide range of diseases, so the genetic and epigenetic abnormalities have not been fully elucidated. Our hospital is one of the 15 pediatric cancer base hospitals nationwide. We have experienced a large number of relapsed / refractory cancer cases, and detailed clinical information on each case is also preserved. We conducted a comprehensive genomic analysis using tumor tissue, non-tumor tissue, and germline tissue of pediatric solid tumor patients which we experienced at our hospital. In addition, we will clarify the abnormalities peculiar to pediatric cancer by comparing them with the genomic information of adult cancer cases.
Methods
We developed more efficient DNA extraction methods using FFPE tissues of pediatric and adult cancer patients and compared the data from whole genome sequencing (WGS) analysis and target capture sequencing (TCS) analysis.
Participants/materials
[WGS]
・Colorectal cancer: 24 cases (FFPE non-tumor tissues)
・Retinoblastoma: 1 case (FFPE tumor tissues)
[TCS]
・Glioblastoma: 2 cases (peripheral blood, fresh frozen tumor tissues, and FFPE tumor tissues)
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000640NGS (WGS, Target Capture)
  • WGS
  • Targeted DNA sequencing
Controlled-access (Type I)2022-08-05

Data provider

Principal investigator
Utako Oba
Affiliation
Department of Pediatrics, Kyusyu University

Research projects

No research projects.

Grants

No grants.

Related publications

TitleDOIDataset ID
An efficient procedure for the recovery of DNA from formalin-fixed paraffin-embedded tissue sections
https://doi.org/10.1093/biomethods/bpac014 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.