hum0303-v1Release info

Monitoring Recurrence of Individual tumor by serial Observation of Known gene Alterations: MORIOKA study

Aims

In our previous studies on advanced esophageal, gastric, and colorectal carcinomas, measurement of circulating tumor DNA (ctDNA) in terms of variant allele frequency (VAF) in blood suggested: (1) patients with high VAF have a high chance of relapse; (2) VAF changes in response to treatment; and (3) ctDNA VAF elevation precedes imaging diagnosis of relapse. It is thus necessary to investigate whether these findings can be generalized in a wide cancer spectrum, types of treatment, and relapse phenotypes across cancer types. In the present study, we conduct a non-interventional observational study in a wide cancer spectrum on the basis of technical establishment for ctDNA using our unique digital PCR probe library.

Methods

Mutations are determined using NGS sequencing panels.

Participants/materials

The subjects are 17 types (lung, ovary, bone, renal, brain, bladder, gastric, duodenal amupullar, pancreas, colon, esophageal, oral, tongue, middle pharynx, gingiva, liver) of malignant tumors. Among 108 cases, 54 cases include 54 tumor and 54 control blood samples, while 54 cases include only tumors.

URL

N/A

Principal investigator

Satoshi S Nishizuka

Affiliation

Division of Biomedical Research & Development, Institute for Biomedical Sciences, Iwate Medical University

No research projects.

No related publications.

No use of the controlled access data has been recorded.