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Research ID

hum0289-v1Release info

Latest

Research title

Mechanisms on relapse after allogeneic hematopoietic cell transplantation in CMML

Research overview

Aims
Disease relapse is a major cause of treatment failure after allogeneic hematopoietic cell transplantation (HCT), and mechanisms on relapse still remain to be elucidated. We experienced a patient with chronic myelomonocytic leukemia (CMML) who underwent haploidentical HCT from his daughter and developed relapse. To understand the mechanisms on relapse after HCT, we analyze blood samples at HCT and at relapse.
Methods
We analyzed peripheral blood samples that had been collected at HCT and relapse. CD14+/CD16- monocytes that accumulate typically in CMML were isolated by flow cytometry. Whole-exome sequencing, RNA sequencing, and methylation array were performed to determine the mechanism of relapse.
Participants/materials
chronic myelomonocytic leukemia (CMML): 1 case; peripheral blood samples that had been collected at allogeneic hematopoietic cell transplantation and relapse (2 samples)
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000428NGS (RNA-seq)
NGS (Exome)
Methylation array
  • RNA-seq
  • WES
  • メチル化アレイ
Controlled-access (Type I)2021-07-31

Data provider

Principal investigator
Yu Akahoshi
Affiliation
Saitama Medical Center, Jichi Medical University

Research projects

No research projects.

Grants

No grants.

Related publications

TitleDOIDataset ID
Emergence of clone with PHF6 nonsense mutation in chronic myelomonocytic leukemia at relapse after allogeneic HCT
https://doi.org/10.1007/s12185-021-03284-7 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.