Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0249-v2Release info

Latest

Research title

Elucidation of pathological conditions and development of therapeutic methods using iPS cells derived from patients with hard tissue/connective tissue related diseases

Research overview

Aims: Elucidation of pathological conditions and development of therapeutic methods using iPS cells derived from patients with hard tissue/connective tissue related diseases
Methods: Cap Analysis of Gene Expression (CAGE)-seq, single-cell RNA-seq, and CUT＆RUN-seq
Participants/materials: iPS cells derived from patients with hard tissue/connective tissue related diseases (genetic defect in RUNX2 positive)
URL: N/A

Datasets

Cart	Dataset ID	Type of data	Analysis method	Access criteria	Date published
	JGAD000348	NGS (CAGE-seq)	CAGE-seq	Controlled-access (Type I)	2020-09-28
	JGAD000793	NGS (scRNA-seq, CUT＆RUN-seq)	scRNA-seq CUT&RUN-seq	Controlled-access (Type I)	2025-04-14

Data provider

Principal investigator: Toshifumi Azuma
Affiliation: Tokyo Dental College / Biochemistry

Research projects

Name	URL
Tokyo Dental College Research Branding Project	N/A

Grants

Name	Title	Project number
KAKENHI Grant-in-Aid for Scientific Research (C)	The osteoblast differentiation control mechanism based on a new concept	19K10063
KAKENHI Grant-in-Aid for Scientific Research (B)	The osteoblast differentiation and calcification mechanism of GNAS-cAMP pathway using diseased iPS cells	18H03007
Tokyo Dental College Research Branding Project	N/A	N/A

Related publications

Title	DOI	Dataset ID
CAGE-seq analysis of osteoblast derived from cleidocranial dysplasia human induced pluripotent stem cells	https://doi.org/10.1016/j.bone.2020.115582 (opens in a new tab)	JGAD000348
Intracellular tension generated by RUNX2-induced LINC complex formation creates a nuclear environment essential for bone differentiation	N/A	JGAD000793

Controlled access users

No use of the controlled access data has been recorded.