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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0214-v2Release info

This page is a past version (v2). The latest version is v10.
Latest version (v10)

Research title

Integrative understanding of human immune system by functional genomics and development of intervention strategies for the prevention of autoimmune diseases

Research overview

Aims
To elucidate the regulation of gene expression in each immune cell subset and its contribution to autoimmune diseases.
Methods
Various immune cell subsets from 21 systemic sclerosis patients, 26 ANCA associated vasculitis, and 28 healthy controls were collected (Naive_B, SM_B, USM_B, DN_B, Plasmablast, Th1, Th2, Th17, Tfh, Naive_CD4, Mem_CD4, Fr._II_eTreg, Naive_CD8, Mem_CD8, mDC, pDC, CD16p_Mono, CD16n_Mono, NK, Neu) and total RNAs were extracted from each subset. RNA-seq was performed for each sample.
Participants/materials
Systemic Sclerosis, ANCA-associated Vasculitis, healthy individuals
URL

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000309NGS (RNA-seq: Systemic sclerosis)
  • RNA-seq
Controlled-access (Type I)2021-03-09
JGAD000310NGS (RNA-seq: Systemic sclerosis)
  • RNA-seq
Controlled-access (Type I)2021-03-09

Data provider

Principal investigator
Keishi Fujio
Affiliation
Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo

Research projects

Grants

NameTitleProject number
Collaborative research fund with Chugai Pharmaceutical Co., Ltd.
N/A
N/A

Related publications

TitleDOIDataset ID
Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis
https://doi.org/10.1016/j.jaut.2020.102547 (opens in a new tab)
Identifying the most influential gene expression profile in distinguishing ANCA-associated vasculitis from healthy controls
https://doi.org/10.1016/j.jaut.2021.102617 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31
Ana Rita GrossoComputational Multi-Omics Lab, Department of Life Sciences, Universidade Nova de Lisboa - NOVA School of Science and TechnologyPortugalAssessing transcriptional dyregulation of repetitive elements and monoallelic-expressed genes in lupus2023-04-25 – 2026-04-10
jiucun wangjiu-cunwang lab , jiu-cun wang , department of anthropology and human genetics, department of anthropology and human genetics of fudan universityChinaThe role and mechanism study of glycosyltransferase-B3GNT2 in regulating macrophages of Ankylosing Spondylitis2023-03-08 – 2024-03-01
Jacob JaffeData Science, Odyssey TherapeuticsMassachusetts, United StatesInvestigation of immune cell transition states in autoimmune disease2023-04-06 – 2023-11-02
yoshito takedaDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka UniversityJapanPathophysiology and diagnostic development with a focus on extracellular vesicles in respiratory and immunological diseases2023-04-12 – 2025-01-17
Yong-Fei WANGWarshel Institue for Computational Biology, School of Medicine, The Chinese University of Hong Kong, ShenzhenChinaInvestigating the Molecular Mechanisms of Systemic Lupus Erythematosus Using Functional Genomics Data2023-06-21 – 2025-05-28
Shimpei KubotaMolecular Psychoneuroimmunology, Hokkaido UniversityJapanGene expression and IL-6 amplifying circuit activators in rheumatoid arthritis and systemic lupus erythematosus2024-02-26 – 2026-03-31
Timothy Vysemolecular and medical genetics, King's College LondonUnited KingdomSequencing Based Genetic Analysis of Systemic Lupus2023-08-25 – 2025-10-16
Hironao SuzukiPharmacology Department, Drug Research Center, Kaken Pharmaceutical,co.,LTD.JapanBioinformatics analysis of immune cells from SLE patients2024-05-09 – 2025-04-17
Hui LiDepartment of Pathology, University of VirginiaUnited StatesGene fusions and RNA Trans-splicing in normal and neoplastic human cells2025-06-25 – 2026-12-31
Tatsuma BanDepartment of Immunology, Graduate School of Medicine, Yokohama City UniversityJapanPathophysiology and therapeutic development of autoimmune diseases focusing on transcription factors of the immune system2024-11-12 – 2027-03-31
Pranidhi SoodWield Therapeutics, IncCalifornia, United StatesIdentifying Gene Expression Based Biomarkers in Patients with Autoimmune Diseases to Predict Response to New Therapies Developed by Wield Therapeutics2025-06-25 – 2027-04-23
Isao MatsumotoDepartment of Rheumatology, Institute of Medicine, University of TsukubaJapanInvestigation of aging-related functional alterations in CD4⁺ T cells in rheumatoid arthritis and experimental arthritis models2025-12-05 – 2029-03-31
Eisuke ItakuraGraduate School of Science, Chiba UniversityJapanLinking SLE Symptoms to Gene Expression Variation through ImmuNexUT2025-10-27 – 2026-04-02