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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0195-v3Release info

Latest

Research title

Comprehensive genetic analysis of gastrointestinal and hepatobiliary tumor

Research overview

Aims
To elucidate the genetic changes in the progression of gastrointestinal and hepatobiliary tumors
Methods
whole genome sequencing, whole exome sequencing, RNA sequencing, and targeted deep sequencing analysis
Participants/materials
- nodule-in-nodule hepatocellular carcinoma
- liver cirrhosis and hepatocellular carcinoma after hepatitis C virus eradication, hepatitis C virus-positive cirrhosis and hepatocellular carcinoma, and hepatitis C virus-negative hepatocellular carcinoma
- gastric cancer and gastric submucosal tumor
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000273NGS (WGS)
  • WGS
Controlled-access (Type I)2021-04-02
JGAD000331NGS (Exome, RNA-seq)
  • WES
Controlled-access (Type I)2021-04-02
JGAD000375NGS (Exome, Target Capture, RNA-seq)
  • WES
  • RNA-seq
  • Targeted DNA sequencing
Controlled-access (Type I)2022-03-04
JGAD000629NGS (Exome)
  • WES
Controlled-access (Type I)2022-03-04
JGAD000332NGS (Exome, RNA-seq)
  • RNA-seq
Controlled-access (Type I)2021-04-02

Data provider

Principal investigator
Atsushi Takai
Affiliation
Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (C)
Exploration for the molecular mechanism on multistep hepatocarcinogenesis using organoid culture system and whole genome sequencing analysis
  • 19K08443
KAKENHI Grant-in-Aid for Scientific Research (B)
Role of regeneration nodule in cirrhotic liver on tumorigenesis
  • 17H04158

Related publications

TitleDOIDataset ID
Multiregional whole-genome sequencing of hepatocellular carcinoma with nodule-in-nodule appearance reveals stepwise cancer evolution
https://doi.org/10.1002/path.5533 (opens in a new tab)
Oncogenic transcriptomic profile is sustained in the liver after the eradication of the hepatitis C virus
https://doi.org/10.1093/carcin/bgab014 (opens in a new tab)
DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis
https://doi.org/10.1038/s41598-020-78151-2 (opens in a new tab)
Expansion of gastric intestinal metaplasia with copy number aberrations contributes to field cancerization
https://doi.org/10.1158/0008-5472.CAN-21-1523 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Jinyan HuangZhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. Biomedical big data center, the First Affiliated Hospital, Zhejiang UniversityChinaComprehensive analysis of alternative splicing in malignant tumors2022-03-15 – 2024-01-01
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31