HumanDBs

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NBDC Research ID:hum0139-v1

Release info

Latest

Title

Research for drug discovery and elucidation of pathophysiology using disease-specific iPS cells

Research overview

Aims: To address how status of KRAS in iPS cells impacts upon self-renewal and differentiation propensity

Methods: Roles of KRAS on stemness were investigated in the context of induced pluripotent stem cells (iPSCs). KRAS mutant (G13C/WT) and wild-type isogenic (WT/WT) iPSCs from a Ras-associated autoimmune leukoproliferative disorder (RALD) patient were used. Retention of self-renewal and capacity for neuronal differentiation were compared.

Targets: A RALD patient-derived iPSC clones (one with KRAS G13C mutation and the other one with no mutation derived from the same patient).

Datasets

	Dataset ID	Access type	Type of data	Release date
	JGAD000205	Controlled-access (Type I)	NGS (Exome)	2020-09-28

Data provider

Principal Investigator: Makoto Otsu
Affiliation: Institute of Medical Science, University of Tokyo

Research projects

Name	URL
The program for intractable diseases research utilizing disease-specific iPS cells

Grants

Name	Title	Project number
Research Center Network for Realization of Regenerative Medicine, Japan Agency for Medical Research and Development (AMED)	The program for intractable diseases research utilizing disease-specific iPS cells	JP16bm0609006 JP17bm0804004

Related publications

Title	DOI	Datasets
Status of KRAS in iPS cells impacts upon self-renewal and differentiation propensity.	https://doi.org/10.1016/j.stemcr.2018.06.008	JGAD000205

Controlled access users

Principal Investigator	Affiliation	Country/Region	Research title	Period of data use	Data in use (Dataset ID)
No data