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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0139-v1Release info

Latest

Research title

Research for drug discovery and elucidation of pathophysiology using disease-specific iPS cells

Research overview

Aims
To address how status of KRAS in iPS cells impacts upon self-renewal and differentiation propensity
Methods
Roles of KRAS on stemness were investigated in the context of induced pluripotent stem cells (iPSCs). KRAS mutant (G13C/WT) and wild-type isogenic (WT/WT) iPSCs from a Ras-associated autoimmune leukoproliferative disorder (RALD) patient were used. Retention of self-renewal and capacity for neuronal differentiation were compared.
Participants/materials
A RALD patient-derived iPSC clones (one with KRAS G13C mutation and the other one with no mutation derived from the same patient).
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000205NGS (Exome)
  • WES
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Makoto Otsu
Affiliation
Institute of Medical Science, University of Tokyo

Research projects

NameURL
The program for intractable diseases research utilizing disease-specific iPS cells
N/A

Grants

NameTitleProject number
Research Center Network for Realization of Regenerative Medicine, Japan Agency for Medical Research and Development (AMED)
The program for intractable diseases research utilizing disease-specific iPS cells
  • JP16bm0609006
  • JP17bm0804004

Related publications

TitleDOIDataset ID
Status of KRAS in iPS cells impacts upon self-renewal and differentiation propensity.
https://doi.org/10.1016/j.stemcr.2018.06.008 (opens in a new tab)

Controlled access users

No use of the controlled access data has been recorded.