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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0136-v2Release info

This page is a past version (v2). The latest version is v3.

Latest version (v3)

Research title

Construction of integrated clinical genome database regarding hepatitis B related diseases

Research overview

Aims: To identify host genetic factors associated with response to a HB vaccination
Methods: Genome-wide association study
Participants/materials: 1,193 Japanese individuals vaccinated with a HB vaccine (Bimmugen) and 555 Japanese individuals vaccinated with a HB vaccine (Heptavax)
URL: N/A

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

Cart	Dataset ID	Type of data	Analysis method	Access criteria	Date published
	NHA000071	GWAS for 1,193 Japanese individuals vaccinated with a HB vaccine (Bimmugen)	Genotyping by array	Unrestricted-access	2018-05-22
	NHA000160	GWAS for 555 Japanese individuals vaccinated with a HB vaccine (Heptavax)	Genotyping by array	Unrestricted-access	2021-03-05

Data provider

Principal investigator: Masashi Mizokami
Affiliation: Natinal Center for Global Health and Medicine

Research projects

Name	URL
Genome Medical Science Project	https://kohnodai.jihs.go.jp/genome/english/index.html (opens in a new tab)

Grants

Name	Title	Project number
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for an Integrated Database of Clinical and Genomic Information	Construction of integrated clinical genome database regarding hepatitis B related diseases	JP16kk0205007
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for Basic and Clinical Research on Hepatitis	Identification of genes associated with hepatitis B virus-related diseases by genome-wide analyses	JP16fk021010
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program on the Innovative Development and the Application of New Drugs for Hepatitis B	Elucidation of the pathogenesis for HBV clearance, chronic hepatitis B infection, and hepatocellular carcinoma	JP17fk0310115
KAKENHI Grant-in-Aid for Scientific Research (C)	Comprehensive understanding for the relationship between HLA class II genes and chronic hepatitis B infection	16K09387
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for Basic and Clinical Research on Hepatitis	Study for clinical sequening based on genome analysis of host and viral factors	JP20fk0210056

Related publications

Title	DOI	Dataset ID
Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine	https://doi.org/10.1002/hep.29876 (opens in a new tab)	NHA000071
Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines	https://doi.org/10.1038/s41598-021-82986-8 (opens in a new tab)	NHA000160