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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
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Dataset ID

NHA000071

Type of data
GWAS for 1,193 Japanese individuals vaccinated with a HB vaccine (Bimmugen)
Access criteria
Unrestricted-access
Total data volume
7.5 MB
File formats
  • XLSX
  • ZIP
Research
hum0136
Date published
2018-05-22
Date modified
2018-05-22
Secondary ID
hum0136.v1.gwas.v1

Unrestricted-access files linked to this dataset

Download the URL list
FileLabelSizeCopy URL
hum0136.v1.gwas.v1.zip7.4 MB
hum0136_header_definition.xlsxDictionary file17.7 KB

Analysis method

Genotyping by array

Materials and participants
1,193 Japanese individuals vaccinated with a HB vaccine (Bimmugen)
- Low responders (n=107, HBsAb ≤ 10mIU/mL)
- Intermediate responders (n=351, 10mIU/mL < HBsAb ≤ 100mIU/mL)
- High responders (n=735, HBsAb >100mIU/mL)
864 Japanese individuals under the age of 30 years vaccinated with a HB vaccine (Bimmugen)
- Low responders (n=56, HBsAb ≤ 10mIU/mL)
- Intermediate responders (n=226, 10mIU/mL < HBsAb ≤ 100mIU/mL)
- High responders (n=582, HBsAb >100mIU/mL)
  • Health status
    Healthy
  • Subject count
    1193 (Individual)
  • Population
    Japanese
  • Age group
    Mixed
Sample description
DNAs extracted from peripheral blood cells
  • Tissue
    Peripheral blood
  • Tumor / normal
    Normal
Sample provider
N/A
Experimental method
Genotyping by array
Target
N/A
Reagent kit
Axiom 2.0 Reagent Kit
Platform
Affymetrix Axiom Genome-Wide ASI 1 Array
Reference genome
GRCh37
QC and filtering
overall call rate < 0.95, SNP call rate < 0.95,
HWE P < 0.001, MAF < 0.05, Regression P < 0.05
Analysis method
GenCall software (Genotyping Console ver. 4.2.0.26)
Variant count
I. Regression analysis for low (0), intermediate (1), and high (2) responders (covariates: age and gender): 22,044 SNPs (Figure 2)
II. Regression analysis for low (0), intermediate (1), and high (2) responders under the age of 30 years (covariates: age and gender): 21,580 SNPs (Supplementary Figure 4)
III. Regression analysis for low (0) and high (1) responders (covariates: age and gender): 23,765 SNPs (Supplementary Figure 5)
Data use policy
NBDC data sharing policy (JGAP000001)