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We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0136-v3Release info

Latest

Research title

Construction of integrated clinical genome database regarding hepatitis B related diseases

Research overview

Aims
To identify host genetic factors associated with response to a HB vaccination
Methods
Genome-wide association study
Participants/materials
1,193 Japanese individuals vaccinated with a HB vaccine (Bimmugen) and 555 Japanese individuals vaccinated with a HB vaccine (Heptavax)
URL
N/A

Datasets

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000452Genotypes for 1,193 Japanese individuals vaccinated with a HB vaccine (Bimmugen)
  • Genotyping by array
Controlled-access (Type I)2021-09-28
NHA000071GWAS for 1,193 Japanese individuals vaccinated with a HB vaccine (Bimmugen)
  • Genotyping by array
Unrestricted-access2018-05-22
NHA000160GWAS for 555 Japanese individuals vaccinated with a HB vaccine (Heptavax)
  • Genotyping by array
Unrestricted-access2021-03-05

Data provider

Principal investigator
Masashi Mizokami
Affiliation
Natinal Center for Global Health and Medicine

Research projects

Grants

NameTitleProject number
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for an Integrated Database of Clinical and Genomic Information
Construction of integrated clinical genome database regarding hepatitis B related diseases
  • JP16kk0205007
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for Basic and Clinical Research on Hepatitis
Identification of genes associated with hepatitis B virus-related diseases by genome-wide analyses
  • JP16fk021010
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program on the Innovative Development and the Application of New Drugs for Hepatitis B
Elucidation of the pathogenesis for HBV clearance, chronic hepatitis B infection, and hepatocellular carcinoma
  • JP17fk0310115
KAKENHI Grant-in-Aid for Scientific Research (C)
Comprehensive understanding for the relationship between HLA class II genes and chronic hepatitis B infection
  • 16K09387
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for Basic and Clinical Research on Hepatitis
Study for clinical sequening based on genome analysis of host and viral factors
  • JP20fk0210056

Related publications

TitleDOIDataset ID
Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine
https://doi.org/10.1002/hep.29876 (opens in a new tab)
Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines
https://doi.org/10.1038/s41598-021-82986-8 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
TAKU MIYAGAWASleep Disorders Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical ScienceJapanSearch for genes involved in the pathogenesis of sleep disorders presenting with hypersomnia (various hypersomnias, circadian rhythm sleep disorders, sleep apnea syndrome, sleep-related movement disorders, sleep paralysis, etc.) and study of their functions and autoantigen-specific responses of peripheral blood lymphocytes2023-07-21 – 2027-03-31