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Due to system maintenance, the application system, application review by the Data Access Committee will be unavailable during the following period.
Schedule: October 5th (Mon), 2026, 9:00 - October 7th (Wed), 2026, 15:00 (JST)
We apologize for any inconvenience this may cause and appreciate your understanding.

We are currently receiving a large number of applications for data submission, and the review process is taking longer than usual.We sincerely apologize for the delay and kindly ask for your understanding. When submitting an application, we would greatly appreciate it if you could allow sufficient time for the processing.

Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Release info for hum0116

  • hum0116-v2

    2025-12-04
    Datasets added in this release
    Release note
    Purified AML blasts from n=1 patient were engrafted into recipient mice to generate PDX (n=10). PDX were infused with CAR-T cells derived from cord blood of five healthy donors (with or without enforced CXCR4 expression; 10 total conditions). CAR-T cells of healthy-donor origin and leukemia cells of patient origin were purified 2.5 weeks (liver, spleen; CAR-T cells and AML blasts) and at either 4 weeks or 5 months (bone marrow; CAR-T cells only) by cell sorting. Single-cell RNA-seq data generated from the sorted cells (FASTQ files) are provided as part of this submission.

  • hum0116-v1

    2020-11-20
    Datasets added in this release
    Release note
    - DNAs extracted from leukemia stem cells, pre-leukemia stem cells, T-cell, B-cells, and leukemia stem cells from humanized mice were used for the Target Capture sequencing analysis (fastq files). Libraries were prepared by using of KAPA Hyper Prep kit and xGen® Acute Myeloid Leukemia Cancer Panel and sequenced by HiSeq 1500 (single-end: 50 bp).
    - DNAs extracted from peripheral blood, bone marrow aspirate from AML patients and human leukemia cells from spleen and bone marrow aspirate of humanized mice with leukemia derived from immune deficiency mice which were infused with peripheral blood, bone marrow aspirate or samples from patients with AML were used for the Target Capture sequencing analysis (fastq files). 1st PCR was performed to amplify target regions from blood derived or manipulated DNAs, followed by the 2nd PCR to add 8-bp barcode and adapter sequences. Then, DNA libraries were sequenced by HiSeq 2500 (paired-end).