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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0116-v1Release info

This page is a past version (v1). The latest version is v2.
Latest version (v2)

Research title

Development of hunanized mice for human immunity research

Research overview

Aims
This study aims to bridge the gap between mouse models and human disease. To this end, we identified somatic mutations associated with human acute myelogenous leukemia (AML) pathogenesis using leukemia cells derived from human leukemia stem cells and from patient-derived xenograft (PDX) mice, which recapitulate human disease by transplanting leukemia stem cells into immunodeficient mice. Furthermore, focusing on AML and the development of chimeric antigen receptor (CAR) T-cell therapy, we investigated how enforced expression of the chemokine receptor CXCR4 promotes memory acquisition and long-term persistence of CAR-T cells, thereby enhancing both the therapeutic efficacy and durability against leukemia.
Methods
Target Capture sequencing (Acute Myeloid Leukemia Cancer Panel and 41 genes), single cell RNA sequencing
Participants/materials
Leukemia stem cells from AML patients or humanized mice with leukemia derived from immune deficiency mice which were infused with human leukemia stem cells, human cord blood-derived CAR-T cells (with or without CXCR4 overexpression) injected into AML patient-derived xenograft (PDX) mice and collected from liver, spleen, and bone marrow, and patient-derived AML blasts
URL

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000133NGS (Target Capture): AML cancer panel
NGS (Target Capture): 41 genes
  • Targeted DNA sequencing
Controlled-access (Type I)2020-11-24
JGAD000355NGS (Target Capture): AML cancer panel
NGS (Target Capture): 41 genes
  • Targeted DNA sequencing
Controlled-access (Type I)2020-11-24

Data provider

Principal investigator
Fumihiko Ishikawa
Affiliation
Laboratory for Human Disease Models, Riken Center for Integrative Medical Sciences

Research projects

NameURL
Target AML project
N/A

Grants

No grants.

Related publications

TitleDOIDataset ID
Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways
https://doi.org/10.1126/scitranslmed.aao1214 (opens in a new tab)
Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive Acute Myeloid Leukemia
https://doi.org/10.1038/s43018-021-00177-w (opens in a new tab)
CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting
https://doi.org/10.1038/s41467-025-67745-x (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Michiaki HamadaHamada Laboratory, Faculty of Science and Engineering, Waseda UniversityJapanConstruction of RNA-targeted Drug Discovery Database2023-01-05 – 2027-10-31