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Following a change to our organizational structure effective April 1, 2026, this division has been renamed from the "Database Center for Life Science, Joint Support-Center for Data Science Research" to the "Database Division for Life Science (DBCLS), BioData Science Initiative (BSI), National Institute of Genetics (NIG)". Where the former name still appears in the guidelines, please read it as the new name.

Research ID

hum0103-v3Release info

This page is a past version (v3). The latest version is v4.
Latest version (v4)

Research title

Genome sequencing analysis for biliary tract cancer

Research overview

Aims
To investigate genomic alterations of Japanese biliary tract cancers
Methods
DNAs/RNA were extracted from biliary tract cancer and paired non-cancer (normal) tissues. NGS libaraies were prepared by using TruSeq DNA Sample Prep kit (Illumina) for whole genome sequencing (WGS), Nextera Rapid Capture kit (Illumina) / Agilent SureSelect Exome V5 kit for whole exome sequencing (WES) and KAPA RNA HyperPrep Kit / TruSeq Stranded mRNA for RNA sequencing. Sequencing was perfomred by Illumina HiSeq 2000/2500 or NovaSeq 6000.
Participants/materials
Japanese biliary tract cancer patients, normal gallbladder tissue
URL
N/A

Datasets

The list is the one this version published; each dataset's content is shown as it is now.

CartDataset IDType of dataAnalysis methodAccess criteriaDate published
JGAD000117NGS (WGS)
NGS (Exome)
  • WGS
Controlled-access (Type I)2020-09-28
JGAD000403bam/gvcf data of NGS (WGS)
  • WGS
Controlled-access (Type I)2021-05-25
JGAD000118NGS (WGS)
NGS (Exome)
  • WES
Controlled-access (Type I)2020-09-28

Data provider

Principal investigator
Hidewaki Nakagawa
Affiliation
RIKEN Center for Integrative Medical Sciences

Research projects

No research projects.

Grants

NameTitleProject number
KAKENHI Grant-in-Aid for Scientific Research (A)
Elucidation of molecular mechanisms of hepatobiliary and pancreatic cancer by multiomics analysis
  • 18H04049
Project for Cancer Research and Therapeutic Evolution (P-CREATE), Japan Agency for Medical Research and Development (AMED)
Search for seeds for the development of novel immunotherapies and combined immunotherapies by cancer genome analysis
  • JP20cm0106552

Related publications

TitleDOIDataset ID
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations
https://doi.org/10.1016/j.jhep.2018.01.009 (opens in a new tab)
Molecular Classification and Tumor Microenvironment Characterization of Gallbladder Cancer by Comprehensive Genomic and Transcriptomic Analysis
https://doi.org/10.3390/cancers13040733 (opens in a new tab)
Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase
https://doi.org/10.18632/oncotarget.28021 (opens in a new tab)

Controlled access users

Principal investigatorAffiliationCountry/RegionResearch titlePeriod of data useDataset ID
Tatsuhiro ShibataDivision of Cancer Genomics, National Cancer Center Research InstituteJapanStudy the molecular mechanics of tumor development and progression with analysing genomic mutations of liver, pancreatic, lung, colorectal, biliary tract, breast, esophageal, ovarian, cervical, bladder, renal, head-and-neck and bone cancers.2018-09-11 – 2018-11-28
Masayuki YamamotoTohoku Medical Megabank OrganizationJapanConstruction of Japanese whole genome database2019-06-24 – 2022-04-15
Justo Lorenzo BermejoStatistical Genetics Research Group. Institute of Medical Biometry, Heidelberg University HospitalGermanyGenomic characterization of gallbladder tumors from patients worldwide2022-10-13 – 2028-12-31
Takuya YamamotoCenter for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health and NutritionJapanBasic research for vaccine development against gastrointestinal cancer and malignant melanoma based on the identification of novel cancer antigens 2024-11-12 – 2026-03-31